![](/images/graphics-bg.png)
B-Lymphocytes from a Population of Children with Autism Spectrum Disorder and Their Unaffected Siblings Exhibit Hypersensitivity to Thimerosal
Joint Authors
Sharpe, Martyn A.
Gist, Taylor L.
Baskin, David S.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
The role of thimerosal containing vaccines in the development of autism spectrum disorder (ASD) has been an area of intense debate, as has the presence of mercury dental amalgams and fish ingestion by pregnant mothers.
We studied the effects of thimerosal on cell proliferation and mitochondrial function from B-lymphocytes taken from individuals with autism, their nonautistic twins, and their nontwin siblings.
Eleven families were examined and compared to matched controls.
B-cells were grown with increasing levels of thimerosal, and various assays (LDH, XTT, DCFH, etc.) were performed to examine the effects on cellular proliferation and mitochondrial function.
A subpopulation of eight individuals (4 ASD, 2 twins, and 2 siblings) from four of the families showed thimerosal hypersensitivity, whereas none of the control individuals displayed this response.
The thimerosal concentration required to inhibit cell proliferation in these individuals was only 40% of controls.
Cells hypersensitive to thimerosal also had higher levels of oxidative stress markers, protein carbonyls, and oxidant generation.
This suggests certain individuals with a mild mitochondrial defect may be highly susceptible to mitochondrial specific toxins like the vaccine preservative thimerosal.
American Psychological Association (APA)
Sharpe, Martyn A.& Gist, Taylor L.& Baskin, David S.. 2013. B-Lymphocytes from a Population of Children with Autism Spectrum Disorder and Their Unaffected Siblings Exhibit Hypersensitivity to Thimerosal. Journal of Toxicology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-499130
Modern Language Association (MLA)
Sharpe, Martyn A.…[et al.]. B-Lymphocytes from a Population of Children with Autism Spectrum Disorder and Their Unaffected Siblings Exhibit Hypersensitivity to Thimerosal. Journal of Toxicology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-499130
American Medical Association (AMA)
Sharpe, Martyn A.& Gist, Taylor L.& Baskin, David S.. B-Lymphocytes from a Population of Children with Autism Spectrum Disorder and Their Unaffected Siblings Exhibit Hypersensitivity to Thimerosal. Journal of Toxicology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-499130
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499130