Lipids, Lipoproteins, and Age-Related Macular Degeneration
Joint Authors
Handa, James T.
Ebrahimi, Katayoon B.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly.
While excellent treatment has emerged for neovascular disease, treatment for early AMD is lacking due to an incomplete understanding of the early molecular events.
A prominent age-related change is the accumulation of neutral lipid in normal Bruch's membrane (BrM) throughout adulthood and also disease-related BrM accumulations called basal deposits and drusen.
AMD lesion formation has thus been conceptualized as sharing mechanisms with atherosclerotic plaque formation, where low-density lipoprotein (LDL) retention within the arterial wall initiates a cascade of pathologic events.
However, we do not yet understand how lipoproteins contribute to AMD.
This paper explores how systemic and local production of lipoproteins might contribute to the pathogenesis of AMD.
American Psychological Association (APA)
Ebrahimi, Katayoon B.& Handa, James T.. 2011. Lipids, Lipoproteins, and Age-Related Macular Degeneration. Journal of Lipids،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-499183
Modern Language Association (MLA)
Ebrahimi, Katayoon B.& Handa, James T.. Lipids, Lipoproteins, and Age-Related Macular Degeneration. Journal of Lipids No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-499183
American Medical Association (AMA)
Ebrahimi, Katayoon B.& Handa, James T.. Lipids, Lipoproteins, and Age-Related Macular Degeneration. Journal of Lipids. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-499183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499183