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Successful Treatment of Cisplatin Overdose with Plasma Exchange
Joint Authors
Mitsuya, Hiroaki
Hayashi, Naoko
Yamada, Yasuhiro
Nosaka, Kisato
Ikuta, Yoshiaki
Miyanari, Nobutomo
Baba, Hideo
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-11
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Accidental cisplatin overdose has been occurring with an increasing frequency due to expanding usage of the agent.
However, the optimal strategy to treat such patients remains to be established.
Here, we report a case of large cisplatin overdose, successfully managed by plasma exchange, intravenous hydration, granulocyte colony-stimulating factor (G-CSF) administration, and other supportive care.
A 67-year-old man with esophageal carcinoma received a large cisplatin overdose of 240 mg/m2, when he received adjuvant therapy following subtotal esophagectomy.
On day 4, he experienced frank cisplatin toxicities and emergency plasma exchange was initiated.
With 7 cycles of plasma exchange, the cisplatin concentration decreased from 2,350 to 110 ng/mL.
Severe bone marrow suppression with high fever ensued on day 10, which was successfully treated with G-CSF and antibiotics.
Despite moderate hearing sense reduction, he recovered without significant complications.
Immediate plasma exchange with hydration and other care was efficacious in quickly lowering cisplatin concentrations.
American Psychological Association (APA)
Yamada, Yasuhiro& Ikuta, Yoshiaki& Nosaka, Kisato& Miyanari, Nobutomo& Hayashi, Naoko& Mitsuya, Hiroaki…[et al.]. 2010. Successful Treatment of Cisplatin Overdose with Plasma Exchange. Case Reports in Medicine،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-499196
Modern Language Association (MLA)
Yamada, Yasuhiro…[et al.]. Successful Treatment of Cisplatin Overdose with Plasma Exchange. Case Reports in Medicine No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-499196
American Medical Association (AMA)
Yamada, Yasuhiro& Ikuta, Yoshiaki& Nosaka, Kisato& Miyanari, Nobutomo& Hayashi, Naoko& Mitsuya, Hiroaki…[et al.]. Successful Treatment of Cisplatin Overdose with Plasma Exchange. Case Reports in Medicine. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-499196
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499196