Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb
Joint Authors
Nair, Anand
Gillis, Glenn
David, Andrew
Stoufflet, Thaya
Winters, Wallace D.
Sehgal, Inder
Scott, Michael
Kousoulas, Konstantine
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Aloe vera, a common ingredient in cosmetics, is increasingly being consumed as a beverage supplement.
Although consumer interest in aloe likely stems from its association with several health benefits, a concern has also been raised by a National Toxicology Program Report that a nondecolorized whole leaf aloe vera extract taken internally by rats was associated with intestinal mucosal hyperplasia and ultimately malignancy.
We tested a decolorized whole leaf (DCWL) aloe vera, treated with activated charcoal to remove the latex portion of the plant, for genotoxicity in bacteria, acute/subacute toxicity in B6C3F1 mice, and subchronic toxicity in F344 rats.
We found this DCWL aloe vera juice to be nongenotoxic in histidine reversion and DNA repair assays.
Following acute administration, mice exhibited no adverse signs at 3- or 14-day evaluation periods.
When fed to male and female F344 rats over 13 weeks, DCWL aloe led to no toxicity as assessed by behavior, stools, weight gain, feed consumption, organ weights, and hematologic or clinical chemistry profiles.
These rats had intestinal mucosal morphologies—examined grossly and microscopically—that were similar to controls.
Our studies show that oral administration of this DCWL aloe juice has a different toxicology profile than that of the untreated aloe juice at exposures up to 13 weeks.
American Psychological Association (APA)
Sehgal, Inder& Winters, Wallace D.& Scott, Michael& David, Andrew& Gillis, Glenn& Stoufflet, Thaya…[et al.]. 2013. Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb. Journal of Toxicology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-499211
Modern Language Association (MLA)
Sehgal, Inder…[et al.]. Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb. Journal of Toxicology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-499211
American Medical Association (AMA)
Sehgal, Inder& Winters, Wallace D.& Scott, Michael& David, Andrew& Gillis, Glenn& Stoufflet, Thaya…[et al.]. Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb. Journal of Toxicology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-499211
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499211