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Evidence for the Use of Isoflurane as a Replacement for Chloral Hydrate Anesthesia in Experimental Stroke : An Ethical Issue
Joint Authors
Vincent, Bérézowski
Régis, Bordet
Michèle, Bastide
Maud, Pétrault
Pétrault, Olivier
Thavarak, Ouk
Cédrick, Lachaud
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Since an ethical issue has been raised regarding the use of the well-known anesthetic agent chloral hydrate, owing to its mutagenic and carcinogenic effects in animals, attention of neuroscientists has turned to finding out an alternative agent able to meet not only potency, safety, and analgesic efficacy, but also reduced neuroprotective effect for stroke research.
The aim of this study was to compare the potential of chloral hydrate and isoflurane for both modulating the action of the experimental neuroprotectant MK801 and exerting analgesia.
After middle cerebral artery occlusion in rats, no difference was observed in 24 h survival rate, success of ischemia, or infarct volume reduction between both anesthetics.
However, isoflurane exerted a more pronounced analgesic effect than chloral hydrate as evidenced by formalin test 3 hours after anesthesia onset, thus encouraging the use of isoflurane in experimental stroke models.Erratum to “Evidence for the Use of Isoflurane as a Replacement for Chloral Hydrate Anesthesia in Experimental Stroke: An Ethical Issue”dx.doi.org/10.1155/2014/307473
American Psychological Association (APA)
Maud, Pétrault& Thavarak, Ouk& Cédrick, Lachaud& Michèle, Bastide& Vincent, Bérézowski& Pétrault, Olivier…[et al.]. 2014. Evidence for the Use of Isoflurane as a Replacement for Chloral Hydrate Anesthesia in Experimental Stroke : An Ethical Issue. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-499220
Modern Language Association (MLA)
Maud, Pétrault…[et al.]. Evidence for the Use of Isoflurane as a Replacement for Chloral Hydrate Anesthesia in Experimental Stroke : An Ethical Issue. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-499220
American Medical Association (AMA)
Maud, Pétrault& Thavarak, Ouk& Cédrick, Lachaud& Michèle, Bastide& Vincent, Bérézowski& Pétrault, Olivier…[et al.]. Evidence for the Use of Isoflurane as a Replacement for Chloral Hydrate Anesthesia in Experimental Stroke : An Ethical Issue. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-499220
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499220