Hemidesmus indicus and Hibiscus rosa-sinensis Affect Ischemia Reperfusion Injury in Isolated Rat Hearts
Joint Authors
Balaraman, R.
Khandelwal, Vinoth Kumar Megraj
Ravingerová, Táňa
Pancza, Dezider
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hemidesmus indicus (L.) R.
Br.
(HI) and Hibiscus rosa-sinensis L.
(HRS) are widely used traditional medicine.
We investigated cardioprotective effects of these plants applied for 15 min at concentrations of 90, 180, and 360 μg/mL in Langendorff-perfused rat hearts prior to 25-min global ischemia/120-min reperfusion (I/R).
Functional recovery (left ventricular developed pressure—LVDP, and rate of development of pressure), reperfusion arrhythmias, and infarct size (TTC staining) served as the endpoints.
A transient increase in LVDP (32%–75%) occurred at all concentrations of HI, while coronary flow (CF) was significantly increased after HI 180 and 360.
Only a moderate increase in LVDP (21% and 55%) and a tendency to increase CF was observed at HRS 180 and 360.
HI and HRS at 180 and 360 significantly improved postischemic recovery of LVDP.
Both the drugs dose-dependently reduced the numbers of ectopic beats and duration of ventricular tachycardia.
The size of infarction was significantly decreased by HI 360, while HRS significantly reduced the infarct size at all concentrations in a dose-dependent manner.
Thus, it can be concluded that HI might cause vasodilation, positive inotropic effect, and cardioprotection, while HRS might cause these effects at higher concentrations.
However, further study is needed to elucidate the exact mechanism of their actions.
American Psychological Association (APA)
Khandelwal, Vinoth Kumar Megraj& Balaraman, R.& Pancza, Dezider& Ravingerová, Táňa. 2010. Hemidesmus indicus and Hibiscus rosa-sinensis Affect Ischemia Reperfusion Injury in Isolated Rat Hearts. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-499258
Modern Language Association (MLA)
Khandelwal, Vinoth Kumar Megraj…[et al.]. Hemidesmus indicus and Hibiscus rosa-sinensis Affect Ischemia Reperfusion Injury in Isolated Rat Hearts. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-499258
American Medical Association (AMA)
Khandelwal, Vinoth Kumar Megraj& Balaraman, R.& Pancza, Dezider& Ravingerová, Táňa. Hemidesmus indicus and Hibiscus rosa-sinensis Affect Ischemia Reperfusion Injury in Isolated Rat Hearts. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-499258
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499258