Lack of Antilipoprotein Lipase Antibodies in Takayasu's Arteritis
Joint Authors
Shoenfeld, Yehuda
Bonfá, Eloísa
Pereira, Rosa Maria Rodrigues
Viana, Vilma Santos Trindade
De Carvalho, Jozélio Freire
Source
Clinical and Developmental Immunology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-07-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Antilipoprotein lipase (anti-LPL) antibodies were described in rheumatic diseases.
In systemic lupus erythematosus they were highly associated with inflammatory markers and dyslipidemia, and may ultimately contribute to vascular damage.
The relevance of this association in Takayasu's arteritis, which is characterized by major inflammatory process affecting vessels, has not been determined.
Objectives.
To analyze the presence of anti-LPL antibodies in patients with Takayasu's arteritis and its association with inflammatory markers and lipoprotein risk levels.
Methods.
Thirty sera from patients with Takayasu's arteritis, according to ACR criteria, were consecutively included.
IgG anti-LPL was detected by a standard ELISA.
Lipoprotein risk levels were evaluated according to NCEP/ATPIII.
Inflammatory markers included ESR and CRP values.
Results.
Takayasu's arteritis patients had a mean age of 34 years old and all were females.
Half of the patients presented high ESR and 60% elevated CRP.
Lipoprotein NCEP risk levels were observed in approximately half of the patients: 53% for total cholesterol, 43% for triglycerides, 16% for HDL-c and 47% for LDL-c.
In spite of the high frequency of dyslipidemia and inflammatory markers in these patients no anti-LPL were detected.
Conclusions.
The lack of anti-LPL antibodies in Takayasu's disease implies distinct mechanisms underlying dyslipidemia compared to systemic lupus erythematosus.
American Psychological Association (APA)
De Carvalho, Jozélio Freire& Pereira, Rosa Maria Rodrigues& Viana, Vilma Santos Trindade& Bonfá, Eloísa& Shoenfeld, Yehuda. 2009. Lack of Antilipoprotein Lipase Antibodies in Takayasu's Arteritis. Clinical and Developmental Immunology،Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-499287
Modern Language Association (MLA)
De Carvalho, Jozélio Freire…[et al.]. Lack of Antilipoprotein Lipase Antibodies in Takayasu's Arteritis. Clinical and Developmental Immunology No. 2009 (2009), pp.1-4.
https://search.emarefa.net/detail/BIM-499287
American Medical Association (AMA)
De Carvalho, Jozélio Freire& Pereira, Rosa Maria Rodrigues& Viana, Vilma Santos Trindade& Bonfá, Eloísa& Shoenfeld, Yehuda. Lack of Antilipoprotein Lipase Antibodies in Takayasu's Arteritis. Clinical and Developmental Immunology. 2009. Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-499287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499287