The Interleukin-6 Gene Promoter Polymorphism -174 and Atherosclerotic Events in Overweight Transplanted Patients
Joint Authors
Saas, Philippe
Chalopin, Jean-Marc
Gaugler, Beatrice
Courivaud, Cécile
Ducloux, Didier
Deschamps, Marina
Tiberghien, Pierre
Bamoulid, Jamal
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Chronic inflammation plays a pivotal role in atherosclerosis.
We hypothesized that combining overweight and a greater genetic capacity to produce IL-6 predicted by IL-6 gene promoter polymorphism at position -174 (G→C) may allow to identify individuals exhibiting higher IL-6 and C-reactive protein (CRP) concentrations with a higher risk of atherosclerotic events (AE).
The occurrence of AE was analyzed with respect to body mass index, IL-6 gene promoter polymorphism at position -174 (G→C), and other relevant risk factors, retrospectively, in 217 renal transplant recipients and, prospectively, in 132.
Circulating IL-6 concentrations were closely related to BMI (r=0.55, P=.0005).
In overweight patients, serum IL-6 concentration was found to be significantly lower in C carriers than in GG patients (4.2 [1.0–5.1] versus 7.3 pg/mL [4.4–100]; P=.025).
The incidence of AE was higher in overweight GG patients (29.5% versus 10.1%; P=.0003).
In multivariate analysis, overweight-GG had an increased risk to develop AE (HR 2.96 [95% CI 1.09–8.04], P=.034 in the retrospective cohort, and HR 2.99 [95% CI 0.92–9.33], P=.069 in the prospective cohort).
All these data are consistent with a role for both genetic and environmental determinants of inflammation (white adipose tissue mass) in the development of AE in renal transplanted patients.
American Psychological Association (APA)
Bamoulid, Jamal& Courivaud, Cécile& Deschamps, Marina& Gaugler, Beatrice& Tiberghien, Pierre& Chalopin, Jean-Marc…[et al.]. 2011. The Interleukin-6 Gene Promoter Polymorphism -174 and Atherosclerotic Events in Overweight Transplanted Patients. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-499293
Modern Language Association (MLA)
Bamoulid, Jamal…[et al.]. The Interleukin-6 Gene Promoter Polymorphism -174 and Atherosclerotic Events in Overweight Transplanted Patients. Journal of Transplantation No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-499293
American Medical Association (AMA)
Bamoulid, Jamal& Courivaud, Cécile& Deschamps, Marina& Gaugler, Beatrice& Tiberghien, Pierre& Chalopin, Jean-Marc…[et al.]. The Interleukin-6 Gene Promoter Polymorphism -174 and Atherosclerotic Events in Overweight Transplanted Patients. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-499293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499293