Resistance of Subtype C HIV-1 Strains to Anti-V3 Loop Antibodies
Joint Authors
Almond, David
Zolla-Pazner, Susan
Krachmarov, Chavdar
Cardozo, Timothy
Swetnam, James
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
HIV-1’s subtype C V3 loop consensus sequence exhibits increased resistance to anti-V3 antibody-mediated neutralization as compared to the subtype B consensus sequence.
The dynamic 3D structure of the consensus C V3 loop crown, visualized by ab initio folding, suggested that the resistance derives from structural rigidity and non-β-strand secondary protein structure in the N-terminal strand of the β-hairpin of the V3 loop crown, which is where most known anti-V3 loop antibodies bind.
The observation of either rigidity or non-β-strand structure in this region correlated with observed resistance to antibody-mediated neutralization in a series of chimeric pseudovirus (psV) mutants.
The results suggest the presence of an epitope-independent, neutralization-relevant structural difference in the antibody-targeted region of the V3 loop crown between subtype C and subtype B, a difference that we hypothesize may contribute to the divergent pattern of global spread between these subtypes.
As antibodies to a variable loop were recently identified as an inverse correlate of risk for HIV infection, the structure-function relationships discussed in this study may have relevance to HIV vaccine research.
American Psychological Association (APA)
Almond, David& Krachmarov, Chavdar& Swetnam, James& Zolla-Pazner, Susan& Cardozo, Timothy. 2012. Resistance of Subtype C HIV-1 Strains to Anti-V3 Loop Antibodies. Advances in Virology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499301
Modern Language Association (MLA)
Almond, David…[et al.]. Resistance of Subtype C HIV-1 Strains to Anti-V3 Loop Antibodies. Advances in Virology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-499301
American Medical Association (AMA)
Almond, David& Krachmarov, Chavdar& Swetnam, James& Zolla-Pazner, Susan& Cardozo, Timothy. Resistance of Subtype C HIV-1 Strains to Anti-V3 Loop Antibodies. Advances in Virology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499301