Infuence of Microstructure in Drug Release Behavior of Silica Nanocapsules
Joint Authors
Sagarzazu, Amaya
Zoltan, Tamara
Gonzalez, Gema
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Meso- and nanoporous structures are adequate matrices for controlled drug delivery systems, due to their large surface areas and to their bioactive and biocompatibility properties.
Mesoporous materials of type SBA-15, synthesized under different pH conditions, and zeolite beta were studied in order to compare the different intrinsic morphological characteristics as pore size, pore connectivity, and pore geometry on the drug loading and release process.
These materials were characterized by X-ray diffraction, nitrogen adsorption, scanning and transmission electron microscopy, and calorimetric measurements.
Ibuprofen (IBU) was chosen as a model drug for the formulation of controlled-release dosage forms; it was impregnated into these two types of materials by a soaking procedure during different periods.
Drug loading and release studies were followed by UV-Vis spectrophotometry.
All nano- and mesostructured materials showed a similar loading behavior.
It was found that the pore size and Al content strongly influenced the release process.
These results suggest that the framework structure and architecture affect the drug adsorption and release properties of these materials.
Both materials offer a good potential for a controlled delivery system of ibuprofen.
American Psychological Association (APA)
Gonzalez, Gema& Sagarzazu, Amaya& Zoltan, Tamara. 2013. Infuence of Microstructure in Drug Release Behavior of Silica Nanocapsules. Journal of Drug Delivery،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-499307
Modern Language Association (MLA)
Gonzalez, Gema…[et al.]. Infuence of Microstructure in Drug Release Behavior of Silica Nanocapsules. Journal of Drug Delivery No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-499307
American Medical Association (AMA)
Gonzalez, Gema& Sagarzazu, Amaya& Zoltan, Tamara. Infuence of Microstructure in Drug Release Behavior of Silica Nanocapsules. Journal of Drug Delivery. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-499307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499307