The Neuroinflammatory Response in ALS : The Roles of Microglia and T Cells
Joint Authors
Krieger, Charles
Lewis, Coral-Ann
Rossi, Fabio
Manning, John
Source
Neurology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by upper and lower motoneuron death.
Mutations in the gene for superoxide dismutase 1 (SOD1) cause a familial form of ALS and have been used to develop transgenic mice which overexpress human mutant SOD1 (mSOD) and these mice exhibit a motoneuron disease which is pathologically and phenotypically similar to ALS.
Neuroinflammation is a pathological hallmark of many neurodegenerative diseases including ALS and is typified by the activation and proliferation of microglia and the infiltration of T cells into the brain and spinal cord.
Although the neuroinflammatory response has been considered a consequence of neuronal dysfunction and death, evidence indicates that manipulation of this response can alter disease progression.
Previously viewed as deleterious to neuronal survival, recent reports suggest a trophic role for activated microglia in the mSOD mouse during the early stages of disease that is dependent on instructive signals from infiltrating T cells.
However, at advanced stages of disease, activated microglia acquire increased neurotoxic potential, warranting further investigation into factors capable of skewing microglial activation towards a neurotrophic phenotype as a means of therapeutic intervention in ALS.
American Psychological Association (APA)
Lewis, Coral-Ann& Manning, John& Rossi, Fabio& Krieger, Charles. 2012. The Neuroinflammatory Response in ALS : The Roles of Microglia and T Cells. Neurology Research International،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499320
Modern Language Association (MLA)
Lewis, Coral-Ann…[et al.]. The Neuroinflammatory Response in ALS : The Roles of Microglia and T Cells. Neurology Research International No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-499320
American Medical Association (AMA)
Lewis, Coral-Ann& Manning, John& Rossi, Fabio& Krieger, Charles. The Neuroinflammatory Response in ALS : The Roles of Microglia and T Cells. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499320