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Low-Dose Naltrexone for Pruritus in Systemic Sclerosis
Joint Authors
Frech, Edward
Revelo, Monica P.
Scholand, Mary Beth
Markewitz, Boaz
Novak, Kirsten
Frech, Tracy M.
Sawitzke, Allen D.
Markewitz, David
Murtaugh, Maureen
Hatton, Nathan
Source
International Journal of Rheumatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Pruritus is a common symptom in systemic sclerosis (SSc), an autoimmune disease which causes fibrosis and vasculopathy in skin, lung, and gastrointestinal tract (GIT).
Unfortunately, pruritus has limited treatment options in this disease.
Pilot trials of low-dose naltrexone hydrochloride (LDN) for pruritus, pain, and quality of life (QOL) in other GIT diseases have been successful.
In this case series we report three patients that had significant improvement in pruritus and total GIT symptoms as measured by the 10-point faces scale and the University of California Los Angeles Scleroderma Clinical Trials Consortium Gastrointestinal Tract 2.0 (UCLA SCTC GIT 2.0) questionnaire.
This small case series suggests LDN may be an effective, highly tolerable, and inexpensive treatment for pruritus and GIT symptoms in SSc.
American Psychological Association (APA)
Frech, Tracy M.& Novak, Kirsten& Revelo, Monica P.& Murtaugh, Maureen& Markewitz, Boaz& Hatton, Nathan…[et al.]. 2011. Low-Dose Naltrexone for Pruritus in Systemic Sclerosis. International Journal of Rheumatology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-499372
Modern Language Association (MLA)
Frech, Tracy M.…[et al.]. Low-Dose Naltrexone for Pruritus in Systemic Sclerosis. International Journal of Rheumatology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-499372
American Medical Association (AMA)
Frech, Tracy M.& Novak, Kirsten& Revelo, Monica P.& Murtaugh, Maureen& Markewitz, Boaz& Hatton, Nathan…[et al.]. Low-Dose Naltrexone for Pruritus in Systemic Sclerosis. International Journal of Rheumatology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-499372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499372