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The Traditional Japanese Formula Keishibukuryogan Inhibits the Production of Inflammatory Cytokines by Dermal Endothelial Cells
Joint Authors
Ur Rehman, Mati
Furuichi, Megumi
Shimizu, Tadamichi
Yoshihisa, Yoko
Ueda, Chieko
Makino, Teruhiko
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Keishibukuryogan (KBG) is one of the traditional herbal formulations widely administered to patients with blood stagnation for improving blood circulation; currently, it is the most frequently prescribed medicine in Japan.
KBG has been reported to improve conjunctional microcirculation.
The aim of this study was to evaluate the role of KBG and paeoniflorin, a bioactive compound of KBG, in inhibiting the production of inflammatory cytokines using human dermal microvessel endothelial cells (HDMECs).
The authors observed that lipopolysaccharide (LPS; 1 μg/mL) stimulated the secretion of proinflammatory cytokines in HDMECs.
KBG treatment (10 mg/mL) significantly suppressed the mRNA levels of migration inhibitory factor (MIF), interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α in LPS-stimulated cultured HDMECs.
Similarly, paeoniflorin significantly suppressed the mRNA levels of these cytokines in LPS-stimulated cultured HDMECs.
ELISA showed that KBG and paeoniflorin suppressed the production of MIF, IL-6, IL-8, and TNF-α in LPS-stimulated HDMECs.
Moreover, KBG and paeoniflorin decreased the expression of cyclooxygenase-2 and inducible nitric oxide synthase (iNOS) in these cells.
These results suggest that KBG may be useful for improving microvascular inflammation in patients with skin diseases.
American Psychological Association (APA)
Yoshihisa, Yoko& Furuichi, Megumi& Ur Rehman, Mati& Ueda, Chieko& Makino, Teruhiko& Shimizu, Tadamichi. 2010. The Traditional Japanese Formula Keishibukuryogan Inhibits the Production of Inflammatory Cytokines by Dermal Endothelial Cells. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-499373
Modern Language Association (MLA)
Yoshihisa, Yoko…[et al.]. The Traditional Japanese Formula Keishibukuryogan Inhibits the Production of Inflammatory Cytokines by Dermal Endothelial Cells. Mediators of Inflammation No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-499373
American Medical Association (AMA)
Yoshihisa, Yoko& Furuichi, Megumi& Ur Rehman, Mati& Ueda, Chieko& Makino, Teruhiko& Shimizu, Tadamichi. The Traditional Japanese Formula Keishibukuryogan Inhibits the Production of Inflammatory Cytokines by Dermal Endothelial Cells. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-499373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499373