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Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes : In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer”
Joint Authors
Jafari, Seyedeh Fatemeh
Nasri, Siti Fatimah
Abdul Majid, A. M. S.
Haque, Rosenani A.
Iqbal, Muhammad Adnan
al-Rawi, Sawsan S.
Ahamed, Mohamed B. Khadeer
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This paper describes synthesis, characterization (NMR, FT-IR, microanalysis, and X-ray crystallography), in vitro anticancer activity of ortho/para-xylyl linked bis-imidazolium salts (4-5) and respective dinuclear Ag(I) N-heterocyclic carbene (NHC) complexes (6-7).
All the compounds were tested for their cytotoxicity against human colorectal cancer (HCT 116) and breast cancer (MCF-7) cell lines.
According to cell viability measurements using MTT assay, all the complexes (6-7) showed a dose-dependent cytotoxic activity against both the cell lines, whereas respective salts (4-5) proved to be inactive.
The complexes (6-7) demonstrated significant activity with IC50 values range 5.6–20.3 μM for HCT 116 and 1.12–6.38 μM for MCF-7.
5-Fluorouracil was used as standard drug (IC50 = 5.9 μM) for HCT 116, whereas tamoxifen was used as standard drug for MCF-7 (IC50 = 14 μM) cell line.
American Psychological Association (APA)
Haque, Rosenani A.& Nasri, Siti Fatimah& Iqbal, Muhammad Adnan& al-Rawi, Sawsan S.& Jafari, Seyedeh Fatemeh& Ahamed, Mohamed B. Khadeer…[et al.]. 2013. Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes : In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer”. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-499403
Modern Language Association (MLA)
Haque, Rosenani A.…[et al.]. Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes : In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer”. Journal of Chemistry No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-499403
American Medical Association (AMA)
Haque, Rosenani A.& Nasri, Siti Fatimah& Iqbal, Muhammad Adnan& al-Rawi, Sawsan S.& Jafari, Seyedeh Fatemeh& Ahamed, Mohamed B. Khadeer…[et al.]. Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes : In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer”. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-499403
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499403