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Does Q223R Polymorphism of Leptin Receptor Influence on Anthropometric Parameters and Bone Density in Childhood Cancer Survivors?
Joint Authors
Sawicka-Żukowska, Malgorzata
Latoch, Eryk
Krawczuk-Rybak, Maryna
Muszynska-Roslan, Katarzyna
Panasiuk, Anna
Konstantynowicz, Jerzy
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Childhood cancer survivors are in augmented risk for developing obesity.
For many factors leptin and leptin receptor gene polymorphism play an important role in the development and metabolism not only of fat, but also, bone tissue.
The aim of the analysis was to find the relationships between Q223R, leptin levels, and anthropometric parameters.
Patients and Methods.
In the study 74 cancer survivors participated (ALL n=64, lymphomas n=10), and the control group consisted of 51 healthy peers.
Leptin blood concentration was determined by ELISA method.
To estimate leptin receptor gene polymorphism, RFLP method was used.
Bone mineral density (BMD) and content (BMC), fat, and lean tissue measurements were obtained by DXA.
Results.
We found no correlations between serum leptin concentrations and anthropometric parameters nor BMD.
Serum leptin concentrations were significantly lower in the group of cancer survivors compared to controls; however, in those overweight from examined group we found leptin levels higher than those in nonoverweight.
Genotype Q223R was not associated with higher leptin levels, BMI, BMD, body fat or lean tissue.
Conclusion.
To our knowledge, this is the first report describing the relationship between BMD and Q223R polymorphism in childhood cancer survivors.
Further analysis, based on a larger group of patients, is needed to confirm these findings.
American Psychological Association (APA)
Sawicka-Żukowska, Malgorzata& Krawczuk-Rybak, Maryna& Muszynska-Roslan, Katarzyna& Panasiuk, Anna& Latoch, Eryk& Konstantynowicz, Jerzy. 2013. Does Q223R Polymorphism of Leptin Receptor Influence on Anthropometric Parameters and Bone Density in Childhood Cancer Survivors?. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-499460
Modern Language Association (MLA)
Sawicka-Żukowska, Malgorzata…[et al.]. Does Q223R Polymorphism of Leptin Receptor Influence on Anthropometric Parameters and Bone Density in Childhood Cancer Survivors?. International Journal of Endocrinology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-499460
American Medical Association (AMA)
Sawicka-Żukowska, Malgorzata& Krawczuk-Rybak, Maryna& Muszynska-Roslan, Katarzyna& Panasiuk, Anna& Latoch, Eryk& Konstantynowicz, Jerzy. Does Q223R Polymorphism of Leptin Receptor Influence on Anthropometric Parameters and Bone Density in Childhood Cancer Survivors?. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-499460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499460