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Protein Kinase C : One Pathway towards the Eradication of Latent HIV-1 Reservoirs
Joint Authors
Momjian, David
Kulkosky, Joseph
McKernan, Lisa N.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
An effective means to eradicate latent reservoirs in HIV-1-infected individuals remains elusive.
Attempts to purge these reservoirs were undertaken over a decade ago without success.
The subsequent lapse in further clinical attempts since may have been justified as our knowledge of the mechanisms which underpin the latent state still evolves.
Although additional novel molecular antagonists of HIV-1 latency have subsequently been reported, these candidate agents have not been tested in human trials for reservoir ablation.
This review provides an overview of the protein kinase C (PKC) pathway which can be modulated by small molecular agents to induce the expression of latent HIV-1 from within infected reservoir cells.
Some of these agents have been tested against select cancers with seemingly tolerable side effects.
As such, modulation of the PKC pathway may yet be a viable mechanism toward HIV-1 reservoir eradication.
American Psychological Association (APA)
McKernan, Lisa N.& Momjian, David& Kulkosky, Joseph. 2012. Protein Kinase C : One Pathway towards the Eradication of Latent HIV-1 Reservoirs. Advances in Virology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499464
Modern Language Association (MLA)
McKernan, Lisa N.…[et al.]. Protein Kinase C : One Pathway towards the Eradication of Latent HIV-1 Reservoirs. Advances in Virology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-499464
American Medical Association (AMA)
McKernan, Lisa N.& Momjian, David& Kulkosky, Joseph. Protein Kinase C : One Pathway towards the Eradication of Latent HIV-1 Reservoirs. Advances in Virology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499464