Gelsolin Restores Aβ-Induced Alterations in Choroid Plexus Epithelium
Joint Authors
Vargas, Teo
Carro, Eva
Spuch, Carlos
Antequera, Desiree
Ugalde, Cristina
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Histologically, Alzheimer's disease (AD) is characterized by senile plaques and cerebrovascular amyloid deposits.
In previous studies we demonstrated that in AD patients, amyloid-β (Aβ) peptide also accumulates in choroid plexus, and that this process is associated with mitochondrial dysfunction and epithelial cell death.
However, the molecular mechanisms underlying Aβ accumulation at the choroid plexus epithelium remain unclear.
Aβ clearance, from the brain to the blood, involves Aβ carrier proteins that bind to megalin, including gelsolin, a protein produced specifically by the choroid plexus epithelial cells.
In this study, we show that treatment with gelsolin reduces Aβ-induced cytoskeletal disruption of blood-cerebrospinal fluid (CSF) barrier at the choroid plexus.
Additionally, our results demonstrate that gelsolin plays an important role in decreasing Aβ-induced cytotoxicity by inhibiting nitric oxide production and apoptotic mitochondrial changes.
Taken together, these findings make gelsolin an appealing tool for the prophylactic treatment of AD.
American Psychological Association (APA)
Vargas, Teo& Antequera, Desiree& Ugalde, Cristina& Spuch, Carlos& Carro, Eva. 2010. Gelsolin Restores Aβ-Induced Alterations in Choroid Plexus Epithelium. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-499468
Modern Language Association (MLA)
Vargas, Teo…[et al.]. Gelsolin Restores Aβ-Induced Alterations in Choroid Plexus Epithelium. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-499468
American Medical Association (AMA)
Vargas, Teo& Antequera, Desiree& Ugalde, Cristina& Spuch, Carlos& Carro, Eva. Gelsolin Restores Aβ-Induced Alterations in Choroid Plexus Epithelium. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-499468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499468