Comparative Evaluation of Anti-Inflammatory Activity of Curcuminoids, Turmerones, and Aqueous Extract of Curcuma longa
Joint Authors
Agarwal, Amit
Bagad, Ashish Subhash
Allan, Joseph Joshua
Bhaskaran, Natarajan
Source
Advances in Pharmacological Sciences
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Curcuma longa is widely known for its anti-inflammatory activity in traditional system of medicine for centuries and has been scientifically validated extensively.
The present study was conducted to evaluate the anti-inflammatory activity of curcuminoids and oil-free aqueous extract (COFAE) of C.
longa and compare it with that of curcuminoids and turmerones (volatile oil), the bioactive components of C.
longa that are proven for the anti-inflammatory potential.
The activity against inflammation was evaluated in xylene-induced ear edema, cotton pellet granuloma models in albino Swiss mice and albino Wistar rats, respectively.
The results showed that COFAE of C.
longa at three dose levels significantly (P≤0.05) inhibited inflammation in both models, as evidenced by reduction in ear weight and decrease in wet as well as dry weights of cotton pellets, when compared to the vehicle control.
The COFAE of C.
longa showed considerable anti-inflammatory effects against acute and chronic inflammation and the effects were comparable to those of curcuminoids and turmerones.
American Psychological Association (APA)
Bagad, Ashish Subhash& Allan, Joseph Joshua& Bhaskaran, Natarajan& Agarwal, Amit. 2013. Comparative Evaluation of Anti-Inflammatory Activity of Curcuminoids, Turmerones, and Aqueous Extract of Curcuma longa. Advances in Pharmacological Sciences،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-499493
Modern Language Association (MLA)
Bagad, Ashish Subhash…[et al.]. Comparative Evaluation of Anti-Inflammatory Activity of Curcuminoids, Turmerones, and Aqueous Extract of Curcuma longa. Advances in Pharmacological Sciences No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-499493
American Medical Association (AMA)
Bagad, Ashish Subhash& Allan, Joseph Joshua& Bhaskaran, Natarajan& Agarwal, Amit. Comparative Evaluation of Anti-Inflammatory Activity of Curcuminoids, Turmerones, and Aqueous Extract of Curcuma longa. Advances in Pharmacological Sciences. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-499493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499493