The Role of Different Subsets of Regulatory T Cells in Immunopathogenesis of Rheumatoid Arthritis
Joint Authors
Mirshafiey, Abbas
Jadidi-Niaragh, Farhad
Sadria, Reza
Uzayzi, Ghulam Rida
Gol-Ara, Maryam
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is a common autoimmune disease and a systemic inflammatory disease which is characterized by chronic joint inflammation and variable degrees of bone and cartilage erosion and hyperplasia of synovial tissues.
Considering the role of autoreactive T cells (particularly Th1 and Th17 cells) in pathophysiology of RA, it might be assumed that the regulatory T cells (Tregs) will be able to control the initiation and progression of disease.
The frequency, function, and properties of various subsets of Tregs including natural Tregs (nTregs), IL-10-producing type 1 Tregs (Tr1 cells), TGF-β-producing Th3 cells, CD8+ Tregs, and NKT regulatory cells have been investigated in various studies associated with RA and collagen-induced arthritis (CIA) as experimental model of this disease.
In this paper, we intend to submit the comprehensive information about the immunobiology of various subsets of Tregs and their roles and function in immunopathophysiology of RA and its animal model, CIA.
American Psychological Association (APA)
Gol-Ara, Maryam& Jadidi-Niaragh, Farhad& Sadria, Reza& Uzayzi, Ghulam Rida& Mirshafiey, Abbas. 2012. The Role of Different Subsets of Regulatory T Cells in Immunopathogenesis of Rheumatoid Arthritis. Arthritis،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-499503
Modern Language Association (MLA)
Gol-Ara, Maryam…[et al.]. The Role of Different Subsets of Regulatory T Cells in Immunopathogenesis of Rheumatoid Arthritis. Arthritis No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-499503
American Medical Association (AMA)
Gol-Ara, Maryam& Jadidi-Niaragh, Farhad& Sadria, Reza& Uzayzi, Ghulam Rida& Mirshafiey, Abbas. The Role of Different Subsets of Regulatory T Cells in Immunopathogenesis of Rheumatoid Arthritis. Arthritis. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-499503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499503