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Solanine Induces Mitochondria-Mediated Apoptosis in Human Pancreatic Cancer Cells
Joint Authors
Wang, Meng
Wang, Yingxiu
Zhou, Mengtao
Xie, Jianming
Zhang, Qingshun
Zhang, Chunwu
Yu, Suhui
Lv, Chongqing
Sun, Hongwei
Yang, Longlong
Kong, Hongru
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Steroid alkaloids have been suggested as potential anticancer compounds.
However, the underlying mechanisms of how steroid alkaloids inhibit the tumor growth are largely unknown.
Here, we reported that solanine, a substance of steroid alkaloids, has a positive effect on the inhibition of pancreatic cancer cell growth in vitro and in vivo.
In pancreatic cancer cells and nu/nu nude mice model, we found that solanine inhibited cancer cells growth through caspase-3 dependent mitochondrial apoptosis.
Mechanically, solanine promotes the opening of mitochondrial membrane permeability transition pore (MPTP) by downregulating the Bcl-2/Bax ratio; thereafter, Cytochrome c and Smac are released from mitochondria into cytosol to process the caspase-3 zymogen into an activated form.
Moreover, we found that the expression of tumor metastasis related proteins, MMP-2 and MMP-9, was also decreased in the cells treated with solanine.
Therefore, our results suggested that solanine was an effective compound for the treatment of pancreatic cancer.
American Psychological Association (APA)
Sun, Hongwei& Lv, Chongqing& Yang, Longlong& Wang, Yingxiu& Zhang, Qingshun& Yu, Suhui…[et al.]. 2014. Solanine Induces Mitochondria-Mediated Apoptosis in Human Pancreatic Cancer Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-499506
Modern Language Association (MLA)
Sun, Hongwei…[et al.]. Solanine Induces Mitochondria-Mediated Apoptosis in Human Pancreatic Cancer Cells. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-499506
American Medical Association (AMA)
Sun, Hongwei& Lv, Chongqing& Yang, Longlong& Wang, Yingxiu& Zhang, Qingshun& Yu, Suhui…[et al.]. Solanine Induces Mitochondria-Mediated Apoptosis in Human Pancreatic Cancer Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-499506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499506