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A Pilot Study of Urokinase-Type Plasminogen Activator (uPA) Overexpression in the Brush Cytology of Patients with Malignant Pancreatic or Biliary Strictures
Joint Authors
Corasanti, James
Hutson, Alan D.
Schlieman, Michael
Singh, Paramvir
Martinick, Maisie
Gibbs, John F.
Saxena, Rakhee
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We have previously demonstrated that uPA is overexpressed in pancreatic tumors.
In an attempt to diagnose these tumors earlier, we sought to determine whether uPA could be identified in endoscopic retrograde cholangiopancreatography obtained brushings in patients with malignant pancreatic and biliary strictures.
Secondarily, uPA was measured in the serum of this patient population.
uPA overexpression was identified in the cytologic tissue in 8 of 11 patients (72.7%).
Serum analysis demonstrated a 2-fold higher concentration of uPA in the pancreaticobiliary cancer patients (1.27 versus 0.56 ng/mL; P=.0182).
Also, uPA overexpression correlated with serum levels (P<.0001).
This study confirms that uPA can be detected in the ERCP cytologically obtained tissue and is frequently present in a higher concentration in the serum of pancreaticobiliary cancer patients.
A larger sample size will be required to address its value as a sensitive marker for the diagnosis of pancreatic or biliary cancers.
American Psychological Association (APA)
Gibbs, John F.& Schlieman, Michael& Singh, Paramvir& Saxena, Rakhee& Martinick, Maisie& Hutson, Alan D.…[et al.]. 2009. A Pilot Study of Urokinase-Type Plasminogen Activator (uPA) Overexpression in the Brush Cytology of Patients with Malignant Pancreatic or Biliary Strictures. HPB Surgery،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-499511
Modern Language Association (MLA)
Gibbs, John F.…[et al.]. A Pilot Study of Urokinase-Type Plasminogen Activator (uPA) Overexpression in the Brush Cytology of Patients with Malignant Pancreatic or Biliary Strictures. HPB Surgery No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-499511
American Medical Association (AMA)
Gibbs, John F.& Schlieman, Michael& Singh, Paramvir& Saxena, Rakhee& Martinick, Maisie& Hutson, Alan D.…[et al.]. A Pilot Study of Urokinase-Type Plasminogen Activator (uPA) Overexpression in the Brush Cytology of Patients with Malignant Pancreatic or Biliary Strictures. HPB Surgery. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-499511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499511