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What Are the Precursor and Early Lesions of Peripheral Intrahepatic Cholangiocarcinoma?
Joint Authors
Sasaki, Motoko
Ren, Xiang Shan
Nakanuma, Yasuni
Harada, Kenichi
Sato, Yasunori
Tsutsui, Akemi
Source
International Journal of Hepatology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cholangiocarcinoma (CC) is divided into distal, perihilar, and intrahepatic CCs (ICCS), and are further subdivided into large bile duct ICC and peripheral ICC.
In distal and perihilar CC and large duct ICC, biliary intraepithelial neoplasm (BilIN) and intraductal papillary neoplasm (IPN) have been proposed as precursor lesions.
Peripheral ICC, bile duct adenoma (BDA), biliary adenofibroma (BAF), and von Meyenburg complexes (VMCs) are reportedly followed by development of ICCs.
Herein, we surveyed these candidate precursor lesions in the background liver of 37 cases of peripheral ICC and controls (perihilar CC, 34 cases; hepatocellular carcinoma, 34 cases and combined hepatocellular cholangiocarcinoma, 25 cases).
In the background liver of peripheral ICC, BDA and BAF were not found, but there were not infrequently foci of BDA-like lesions and atypical bile duct lesions involving small bile ducts (32.4% and 10.8%, resp.).
VMCs were equally found in peripheral CCs and also control CCs.
In conclusion, BDA, BAF, and VMCs are a possible precursor lesion of a minority of peripheral CCs, and BDA-like lesions and atypical bile duct lesions involving small bile ducts may also be related to the development of peripheral ICC.
Further pathologic studies on these lesions are warranted for analysis of development of peripheral ICCs.
American Psychological Association (APA)
Nakanuma, Yasuni& Tsutsui, Akemi& Ren, Xiang Shan& Harada, Kenichi& Sato, Yasunori& Sasaki, Motoko. 2014. What Are the Precursor and Early Lesions of Peripheral Intrahepatic Cholangiocarcinoma?. International Journal of Hepatology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-499512
Modern Language Association (MLA)
Nakanuma, Yasuni…[et al.]. What Are the Precursor and Early Lesions of Peripheral Intrahepatic Cholangiocarcinoma?. International Journal of Hepatology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-499512
American Medical Association (AMA)
Nakanuma, Yasuni& Tsutsui, Akemi& Ren, Xiang Shan& Harada, Kenichi& Sato, Yasunori& Sasaki, Motoko. What Are the Precursor and Early Lesions of Peripheral Intrahepatic Cholangiocarcinoma?. International Journal of Hepatology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-499512
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499512