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Cancer Risks for Relatives of Children with Cancer
Joint Authors
Algar, Elizabeth M.
Hopper, John L.
Heath, John A.
Smibert, Elizabeth
Dite, Gillian S.
Source
Journal of Cancer Epidemiology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
We determined the extent and distribution of cancers in relatives of 379 children newly diagnosed with cancer.
Family history was collected from 1,337 first-degree and 3,399 second-degree relatives and incidence compared with national age- and gender-specific rates.
Overall, 14 children (3.7%) had a relative with a history of childhood cancer and 26 children (6.9%) had a first-degree relative with a history of cancer, with only one of these having an identifiable familial cancer syndrome.
There was a higher than expected incidence of childhood cancer among first-degree relatives (parents and siblings) (standardized incidence ratio (SIR) 1.43; 95% CI 0.54–5.08).
There was also a higher than expected incidence of adult cancers among first-degree relatives (SIR 1.45; 95% CI 0.93–2.21), particularly in females (SIR 1.82; 95% CI 1.26–3.39).
The increased family cancer history in first-degree females was largely attributable to an effect in mothers (SIR 1.78; 95% CI 1.27–3.33).
The gender-specific association was reflected in higher than expected incidence rates of breast cancer in both mothers (SIR 1.92; 95% CI 0.72–6.83) and aunts (SIR 1.64; 95% CI 0.98–2.94).
These findings support the hypothesis that previously undetected familial cancer syndromes contribute to childhood cancer.
American Psychological Association (APA)
Heath, John A.& Smibert, Elizabeth& Algar, Elizabeth M.& Dite, Gillian S.& Hopper, John L.. 2014. Cancer Risks for Relatives of Children with Cancer. Journal of Cancer Epidemiology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-499523
Modern Language Association (MLA)
Heath, John A.…[et al.]. Cancer Risks for Relatives of Children with Cancer. Journal of Cancer Epidemiology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-499523
American Medical Association (AMA)
Heath, John A.& Smibert, Elizabeth& Algar, Elizabeth M.& Dite, Gillian S.& Hopper, John L.. Cancer Risks for Relatives of Children with Cancer. Journal of Cancer Epidemiology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-499523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499523