The Association of Chronic Kidney Disease and Metabolic Syndrome with Incident Cardiovascular Events : Multiethnic Study of Atherosclerosis

Joint Authors

Agarwal, Subhashish
Shlipak, Michael G.
Herrington, David M.
Kramer, Holly
Jain, Aditya

Source

Cardiology Research and Practice

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-07-26

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases

Abstract EN

Background.

There is an association between chronic kidney disease (CKD) and metabolic syndrome (MetS).

We examined the joint association of CKD and MetS with incident cardiovascular (CVD) events in the Multiethnic Study of Atherosclerosis (MESA) cohort.

Methods.

We analyzed 2,283 Caucasians, 363 Chinese, 1,449 African-Americans, and 1,068 Hispanics in the MESA cohort.

CKD was defined by cystatin C estimated glomerular filtration rate ≤ 60 mL/min/1.73 m2 and MetS was defined by NCEP criteria.

Cox proportional regression adjusting for age, ethnicity, gender, study site, education, income, smoking, alcohol use, physical activity, and total and LDL cholesterol was performed to assess the joint association of CKD and MetS with incident CVD events.

Participants were divided into four groups by presence of CKD and/or MetS and compared to the group without CKD and MetS (CKD−/MetS−).

Tests for additive and multiplicative interactions between CKD and MetS and prediction of incident CVD were performed.

Results.

During follow-up period of 5.5 years, 283 participants developed CVD.

Multivariate Cox regression analysis demonstrated that CKD and MetS were independent predictors of CVD (hazard ratio, 2.02 for CKD, and 2.55 for MetS).

When participants were compared to the CKD−/MetS− group, adjusted HR for the CKD+/MetS+ group was 5.56 (95% CI 3.72–8.12).

There was no multiplicative interaction between CKD and MetS (P=0.2); however, there was presence of additive interaction.

The relative excess risk for additive interaction (RERI) was 2.73, P=0.2, and the attributable portion (AP) was 0.49 (0.24–0.74).

Conclusion.

Our findings illustrate that the combination of CKD and MetS is a strong predictor of incident clinical cardiovascular events due to presence of additive interaction between CKD and MetS.

American Psychological Association (APA)

Agarwal, Subhashish& Shlipak, Michael G.& Kramer, Holly& Jain, Aditya& Herrington, David M.. 2011. The Association of Chronic Kidney Disease and Metabolic Syndrome with Incident Cardiovascular Events : Multiethnic Study of Atherosclerosis. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499527

Modern Language Association (MLA)

Agarwal, Subhashish…[et al.]. The Association of Chronic Kidney Disease and Metabolic Syndrome with Incident Cardiovascular Events : Multiethnic Study of Atherosclerosis. Cardiology Research and Practice No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-499527

American Medical Association (AMA)

Agarwal, Subhashish& Shlipak, Michael G.& Kramer, Holly& Jain, Aditya& Herrington, David M.. The Association of Chronic Kidney Disease and Metabolic Syndrome with Incident Cardiovascular Events : Multiethnic Study of Atherosclerosis. Cardiology Research and Practice. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499527

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-499527