Imiquimod 3.75% Cream Applied Daily to Treat Anogenital Warts : Combined Results from Women in Two Randomized, Placebo-Controlled Studies
Joint Authors
Martens, Mark G.
Levy, Sharon
Tyring, Stephen K.
Ferris, Daron G.
Wu, Jason
Baker, David A.
Liu, Tiepu
Edwards, Libby
Trofatter, Kenneth F.
Ault, Kevin
Fife, Kenneth H.
Nelson, Anita
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
To evaluate if new imiquimod formulations using a shorter treatment duration are safe and efficacious to treat anogenital warts.
Methods.
In two studies 534 women ≥12 years of age (mean 33.4) with 2–30 warts (mean 7.9) and total wart area ≥10 mm2 (mean 166.3) were randomized (1 : 2 : 2) to placebo (106), imiquimod 2.5% (212) or 3.75% (216) creams applied once daily until complete clearance or a maximum of 8 weeks.
Results.
For placebo, imiquimod 2.5% and 3.75%, respectively, complete clearance of all warts was achieved in 14.2%, 28.3%, and 36.6% of women (intent-to-treat, P=0.008 imiquimod 2.5%, and P<0.001 3.75% versus placebo).
Mean changes in wart counts were −10.7%, −50.9%, and −63.5% (per-protocol, P<0.001 each active versus placebo) and safety-related discontinuation rates 0.9%, 1.4%, and 2.3%.
Conclusions.
Imiquimod 3.75% applied daily for up to 8 weeks was well tolerated and superior to placebo in treating women with external anogenital warts.
American Psychological Association (APA)
Baker, David A.& Ferris, Daron G.& Martens, Mark G.& Fife, Kenneth H.& Tyring, Stephen K.& Edwards, Libby…[et al.]. 2011. Imiquimod 3.75% Cream Applied Daily to Treat Anogenital Warts : Combined Results from Women in Two Randomized, Placebo-Controlled Studies. Infectious Diseases in Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-499528
Modern Language Association (MLA)
Baker, David A.…[et al.]. Imiquimod 3.75% Cream Applied Daily to Treat Anogenital Warts : Combined Results from Women in Two Randomized, Placebo-Controlled Studies. Infectious Diseases in Obstetrics and Gynecology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-499528
American Medical Association (AMA)
Baker, David A.& Ferris, Daron G.& Martens, Mark G.& Fife, Kenneth H.& Tyring, Stephen K.& Edwards, Libby…[et al.]. Imiquimod 3.75% Cream Applied Daily to Treat Anogenital Warts : Combined Results from Women in Two Randomized, Placebo-Controlled Studies. Infectious Diseases in Obstetrics and Gynecology. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-499528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499528