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Role of Talc Modulation on Cytokine Activation in Cancer Patients Undergoing Pleurodesis
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We investigate the mechanism of talc pleurodesis (TP) in 20 patients with recurrent malignant pleural effusion and 10 patients with nonmalignant pleural effusions.
We measured IL-8 levels before and 6 h after TP and find a significant threefold increase (2.26 ng/mL ± 0.7 to 6.5 ng/mL 0.1), which explains the recruitment of inflammatory cells in these patients.
We hypothesize that TP is enable by stimulating the mesothelial cells (MS) to secrete FGF.
A significant tenfold increase in FGF-b (0.05 ng/mL ± 0.02 to 0.44 ng/mL 0.6) was seen 24 h after talc instillation (P<0.04).
In order to examine whether FGF-b is secreted by MS cells, MS recovered from CHF patients with recurrent pleural effusions were cultured for 48 h in the presence or absence of increasing concentrations of talc (from 100 ng/mL to 1 mg/mL).
They produced significant levels of FGF-b in a dose dependent manner (P<0.005).
We hypothesized that a successful pleurodesis involves an early enhanced recruitment of inflammatory cells through a rise of IL-8 followed by enrollment of fibroblasts from the submesothelial space through increased mesothelial FGF-b production.
American Psychological Association (APA)
Schwarz, Yehuda& Star, Alex. 2012. Role of Talc Modulation on Cytokine Activation in Cancer Patients Undergoing Pleurodesis. Pulmonary Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-499533
Modern Language Association (MLA)
Schwarz, Yehuda& Star, Alex. Role of Talc Modulation on Cytokine Activation in Cancer Patients Undergoing Pleurodesis. Pulmonary Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-499533
American Medical Association (AMA)
Schwarz, Yehuda& Star, Alex. Role of Talc Modulation on Cytokine Activation in Cancer Patients Undergoing Pleurodesis. Pulmonary Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-499533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499533