When Things Are Not as They Appear : Assessing the Adequacy of Cluster Randomization When Outcome Events Are Rare at Baseline
Joint Authors
Gomez, Perry
Stanton, Bonita F.
Li, Xiaoming
Brathwaite, Nanika
Chen, Xinguang
Deveaux, Lynette
Cottrell, Lesley A.
Dinaj-Koci, Veronica
Lunn, Sonya
Harris, Carole
Marshall, Sharon
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The present study randomly assigned 15 Bahamian elementary schools to one of three intervention conditions.
To assess the adequacy of cluster randomization, we examined two concerns identified by the local research team: inequality of gender distribution and environmental risk among groups.
Baseline significant differences in risk and protective behaviors were minimal.
There were significantly more males in the intervention group.
Males had higher rates of risk behavior at all assessments.
Poor school performance was also higher among the intervention condition and was significantly associated with increased rates of many but not all risk behaviors.
Prior to adjusting for gender and school performance, several risk behaviors appeared to be higher after intervention among intervention youth.
Adjusting for gender and school performance eradicated the group differences in risk behavior rates.
Results demonstrate the importance of adequate randomization where outcomes of interest are rare events at baseline or differ by gender and there is an unequal gender distribution and the importance of the local research team’s knowledge of potential inequalities in environmental risk (i.e., school performance).
Not considering such individual differences could impact the integrity of trial outcomes.
American Psychological Association (APA)
Dinaj-Koci, Veronica& Brathwaite, Nanika& Deveaux, Lynette& Lunn, Sonya& Cottrell, Lesley A.& Harris, Carole…[et al.]. 2012. When Things Are Not as They Appear : Assessing the Adequacy of Cluster Randomization When Outcome Events Are Rare at Baseline. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-499560
Modern Language Association (MLA)
Dinaj-Koci, Veronica…[et al.]. When Things Are Not as They Appear : Assessing the Adequacy of Cluster Randomization When Outcome Events Are Rare at Baseline. AIDS Research and Treatment No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-499560
American Medical Association (AMA)
Dinaj-Koci, Veronica& Brathwaite, Nanika& Deveaux, Lynette& Lunn, Sonya& Cottrell, Lesley A.& Harris, Carole…[et al.]. When Things Are Not as They Appear : Assessing the Adequacy of Cluster Randomization When Outcome Events Are Rare at Baseline. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-499560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499560