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The Thromboembolic Risk in Giant Cell Arteritis : A Critical Review of the Literature
Joint Authors
De Donato, M. T.
Finelli, R.
Caputo, D.
Tufano, Antonella
Perna, P.
Moscato, P.
Di Minno, Matteo Nicola Dario
Guida, Anna
Source
International Journal of Rheumatology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Giant cell arteritis is a systemic vasculitis characterized by granulomatous inflammation of the aorta and its main vessels.
Cardiovascular risk, both for arterial and venous thromboembolism, is increased in these patients, but the role of thromboprophylaxis is still debated.
It should be suspected in elderly patients suffering from sudden onset severe headaches, jaw claudication, and visual disease.
Early diagnosis is necessary because prognosis depends on the timeliness of treatment: this kind of arteritis can be complicated by vision loss and cerebrovascular strokes.
Corticosteroids remain the cornerstone of the pharmacological treatment of GCA.
Aspirin seems to be effective in cardiovascular prevention, while the use of anticoagulant therapy is controversial.
Association with other rheumatological disease, particularly with polymyalgia rheumatica is well known, while possible association with antiphospholipid syndrome is not established.
Large future trials may provide information about the optimal therapy.
Other approaches with new drugs, such as TNF-alpha blockades, Il-6 and IL-1 blockade agents, need to be tested in larger trials.
American Psychological Association (APA)
Guida, Anna& Tufano, Antonella& Perna, P.& Moscato, P.& De Donato, M. T.& Finelli, R.…[et al.]. 2014. The Thromboembolic Risk in Giant Cell Arteritis : A Critical Review of the Literature. International Journal of Rheumatology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-499564
Modern Language Association (MLA)
Guida, Anna…[et al.]. The Thromboembolic Risk in Giant Cell Arteritis : A Critical Review of the Literature. International Journal of Rheumatology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-499564
American Medical Association (AMA)
Guida, Anna& Tufano, Antonella& Perna, P.& Moscato, P.& De Donato, M. T.& Finelli, R.…[et al.]. The Thromboembolic Risk in Giant Cell Arteritis : A Critical Review of the Literature. International Journal of Rheumatology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-499564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499564