![](/images/graphics-bg.png)
The Role of Proteasome Inhibition in Nonsmall Cell Lung Cancer
Joint Authors
Santos, Edgardo S.
Escobar, Mauricio
Raez, Luis E.
Belalcazar, Astrid
Velez, Michel
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Lung cancer therapy with current available chemotherapeutic agents is mainly palliative.
For these and other reasons there is now a great interest to find targeted therapies that can be effective not only palliating lung cancer or decreasing treatment-related toxicity, but also giving hope to cure these patients.
It is already well known that the ubiquitin-proteasome system like other cellular pathways is critical for the proliferation and survival of cancer cells; thus, proteosome inhibition has become a very attractive anticancer therapy.
There are several phase I and phase II clinical trials now in non-small cell lung cancer and small cell lung cancer using this potential target.
Most of the trials use bortezomib in combination with chemotherapeutic agents.
This paper tends to make a state-of-the-art review based on the available literature regarding the use of bortezomib as a single agent or in combination with chemotherapy in patients with lung cancer.
American Psychological Association (APA)
Escobar, Mauricio& Velez, Michel& Belalcazar, Astrid& Santos, Edgardo S.& Raez, Luis E.. 2011. The Role of Proteasome Inhibition in Nonsmall Cell Lung Cancer. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-499574
Modern Language Association (MLA)
Escobar, Mauricio…[et al.]. The Role of Proteasome Inhibition in Nonsmall Cell Lung Cancer. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-499574
American Medical Association (AMA)
Escobar, Mauricio& Velez, Michel& Belalcazar, Astrid& Santos, Edgardo S.& Raez, Luis E.. The Role of Proteasome Inhibition in Nonsmall Cell Lung Cancer. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-499574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499574