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“Almost Bleeding to Death” : The Conundrum of Acquired Amegakaryocytic Thrombocytopenia
Joint Authors
Yeager, Andrew M.
Krishnadasan, Ravitharan
Cantu, Carlos L.
Babiker, Hani M.
Brown, Gabrielle Elena
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Acquired amegakaryocytic thrombocytopenia (AAT) is a rare hematological disorder causing severe thrombocytopenia and bleeding.
Previous in vitro studies postulated both cell-mediated suppression of megakaryocytopoiesis in early megakaryocytic progenitor cells and humoral-mediated suppression by anti-thrombopoietin antibodies as possible etiologies of AAT.
Patients with AAT usually present with severe bleeding and thrombocytopenia that is unresponsive to steroids and intravenous immunoglobulin (IVIG).
Although standard guidelines have not been established for management of AAT, a few case reports have indicated a response to immunosuppressive treatment.
The prompt recognition of this disease entity is essential in view of the substantial risk of morbidity and mortality from excessive bleeding.
We report a case of AAT successfully treated with equine antithymocyte globulin (ATG) and cyclosporine (CSP).
American Psychological Association (APA)
Brown, Gabrielle Elena& Babiker, Hani M.& Cantu, Carlos L.& Yeager, Andrew M.& Krishnadasan, Ravitharan. 2014. “Almost Bleeding to Death” : The Conundrum of Acquired Amegakaryocytic Thrombocytopenia. Case Reports in Hematology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-499578
Modern Language Association (MLA)
Brown, Gabrielle Elena…[et al.]. “Almost Bleeding to Death” : The Conundrum of Acquired Amegakaryocytic Thrombocytopenia. Case Reports in Hematology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-499578
American Medical Association (AMA)
Brown, Gabrielle Elena& Babiker, Hani M.& Cantu, Carlos L.& Yeager, Andrew M.& Krishnadasan, Ravitharan. “Almost Bleeding to Death” : The Conundrum of Acquired Amegakaryocytic Thrombocytopenia. Case Reports in Hematology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-499578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499578