Conditional Gene Targeting : Dissecting the Cellular Mechanisms of Retinal Degenerations
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Retinal neuron degeneration and survival are often regulated by the same trophic factors that are required for embryonic development and are usually expressed in multiple cell-types.
Therefore, the conditional gene targeting approach is necessary to investigate the cell-specific function of widely expressed and developmentally regulated genes in retinal degeneration.
The discussion in this review will be focused on the use of Cre/lox-based conditional gene targeting approach in mechanistic studies for retinal degeneration.
In addition to the basic experimental designs, this article addresses various factors influencing the outcomes of conditional gene targeting studies, limitations of current technologies, availability of Cre-drive lines for various retinal cells, and issues related to the generation of Cre-expressing mice.
Finally, this review will update the current status on the use of Cre/lox-based gene targeting approach in mechanistic studies for retinal degeneration, which includes rod photoreceptor survival under photo-oxidative stress and protein trafficking in photoreceptors.
American Psychological Association (APA)
Le, Yun-Zheng. 2010. Conditional Gene Targeting : Dissecting the Cellular Mechanisms of Retinal Degenerations. Journal of Ophthalmology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-499595
Modern Language Association (MLA)
Le, Yun-Zheng. Conditional Gene Targeting : Dissecting the Cellular Mechanisms of Retinal Degenerations. Journal of Ophthalmology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-499595
American Medical Association (AMA)
Le, Yun-Zheng. Conditional Gene Targeting : Dissecting the Cellular Mechanisms of Retinal Degenerations. Journal of Ophthalmology. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-499595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499595