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Human Tissue in the Evaluation of Safety and Efficacy of New Medicines : A Viable Alternative to Animal Models?
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
The pharma Industry's ability to develop safe and effective new drugs to market is in serious decline.
Arguably, a major contributor to this is the Industry's extensive reliance on nonhuman biology-based test methods to determine potential safety and efficacy, objective analysis of which reveals poor predictive value.
An obvious alternative approach is to use human-based tests, but only if they are available, practical, and effective.
While in vivo (phase 0 microdosing with high sensitivity mass spectroscopy) and in silico (using established human biological data), technologies are increasingly being used, in vitro human approaches are more rarely employed.
However, not only are increasingly sophisticated in vitro test methods now available or under development, but the basic ethically approved infrastructure through which human cells and tissues may be acquired is established.
Along with clinical microdosing and in silico approaches, more effective access to and use of human cells and tissues in vitro provide exciting and potentially more effective opportunities for the assessment of safety and efficacy of new medicines.
American Psychological Association (APA)
Coleman, Robert A.. 2011. Human Tissue in the Evaluation of Safety and Efficacy of New Medicines : A Viable Alternative to Animal Models?. ISRN Pharmaceutics،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-499596
Modern Language Association (MLA)
Coleman, Robert A.. Human Tissue in the Evaluation of Safety and Efficacy of New Medicines : A Viable Alternative to Animal Models?. ISRN Pharmaceutics No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-499596
American Medical Association (AMA)
Coleman, Robert A.. Human Tissue in the Evaluation of Safety and Efficacy of New Medicines : A Viable Alternative to Animal Models?. ISRN Pharmaceutics. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-499596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499596