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Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults
Joint Authors
Sanada, Hironobu
Yatabe, Midori S.
Felder, Robin A.
Yatabe, Junichi
Jose, Pedro A.
Yoneda, Minoru
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
G protein-coupled receptor kinase 4 (GRK4) with activating polymorphisms desensitize the natriuric renal tubular D1 dopamine receptor, and these GRK4 polymorphisms are strongly associated with salt sensitivity and hypertension.
Meanwhile, N-terminal pro-B-type natriuretic peptide (NT-proBNP) may be useful in detecting slight volume expansion.
However, relations between hypertension-related gene polymorphisms including GRK4 and cardiovascular indices such as NT-proBNP are not clear, especially in healthy subjects.
Therefore, various hypertension-related polymorphisms and cardiovascular indices were analyzed in 97 normotensive, healthy Japanese adults.
NT-proBNP levels were significantly higher in subjects with two or more GRK4 polymorphic alleles.
Other hypertension-related gene polymorphisms, such as those of renin-angiotensin-aldosterone system genes, did not correlate with NT-proBNP.
There was no significant association between any of the hypertension-related gene polymorphisms and central systolic blood pressure, cardioankle vascular index, augmentation index, plasma aldosterone concentration, or an oxidative stress marker, urinary 8-OHdG.
Normotensive individuals with GRK4 polymorphisms show increased serum NT-proBNP concentration and may be at a greater risk of developing hypertension and cardiovascular disease.
American Psychological Association (APA)
Yatabe, Junichi& Yatabe, Midori S.& Yoneda, Minoru& Felder, Robin A.& Jose, Pedro A.& Sanada, Hironobu. 2012. Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-499601
Modern Language Association (MLA)
Yatabe, Junichi…[et al.]. Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults. International Journal of Hypertension No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-499601
American Medical Association (AMA)
Yatabe, Junichi& Yatabe, Midori S.& Yoneda, Minoru& Felder, Robin A.& Jose, Pedro A.& Sanada, Hironobu. Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-499601
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499601