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Basal-Like Phenotype in a Breast Carcinoma Case Series from Sudan : Prevalence and ClinicalPathological Correlations
Joint Authors
Biunno, Ida
Elwali, Nasr Eldin
Barberis, Massimo Costanzo
Hamad, Hussein M. A.
Osman, Ihsan
Mekki, Salwa O.
Mariani-Costantini, Renato
Elamin, Elgizouli Omer Musa
Awadelkarim, Khalid Dafaallah
De Blasio, Pasquale
Arizzi, Carmelo
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Basal-like breast cancer, an aggressive subtype associated with high grade, poor prognosis, and younger age, is reported frequently in Africa.
We analyzed the expression of the basal cytokeratins (CKs) 5/6 and 17 in a case series from Central Sudan and investigated correlations among basal CK status, ER, PgR, and Her-2/neu, and individual/clinicopathological data.
Of 113 primary breast cancers 26 (23%), 38 (34%), and 46 (41%) were, respectively, positive for CK5/6, CK17, and combined basal CKs (CK5/6 and/or CK17).
Combined basal CK+ status was associated with higher grade (P<.03) and inversely correlated with ER (P<.002), PgR (P=.004) and combined ER and/or PgR (P<.0002).
Two clusters based on all tested markers were generated by hierarchical cluster analysis and k-mean clustering: I: designated ``hormone receptors positive/luminal-like’’ and II: designated ``hormone receptors negative’’, including both basal-like and Her-2/neu+ tumors.
The most important factors for dataset variance were ER status, followed by PgR, CK17, and CK5/6 statuses.
Overall basal CKs were expressed in a fraction of cases comparable to that reported for East and West African case series.
Lack of associations with age and tumor size may represent a special feature of basal-like breast cancer in Sudan.
American Psychological Association (APA)
Awadelkarim, Khalid Dafaallah& Arizzi, Carmelo& Elamin, Elgizouli Omer Musa& Hamad, Hussein M. A.& De Blasio, Pasquale& Mekki, Salwa O.…[et al.]. 2011. Basal-Like Phenotype in a Breast Carcinoma Case Series from Sudan : Prevalence and ClinicalPathological Correlations. Pathology Research International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-499602
Modern Language Association (MLA)
Awadelkarim, Khalid Dafaallah…[et al.]. Basal-Like Phenotype in a Breast Carcinoma Case Series from Sudan : Prevalence and ClinicalPathological Correlations. Pathology Research International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-499602
American Medical Association (AMA)
Awadelkarim, Khalid Dafaallah& Arizzi, Carmelo& Elamin, Elgizouli Omer Musa& Hamad, Hussein M. A.& De Blasio, Pasquale& Mekki, Salwa O.…[et al.]. Basal-Like Phenotype in a Breast Carcinoma Case Series from Sudan : Prevalence and ClinicalPathological Correlations. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-499602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499602