Unpredictable Nature of Tolvaptan in Treatment of Hypervolemic Hyponatremia : Case Review on Role of Vaptans
Joint Authors
Malhotra, Ishan
Gopinath, Shilpa
Tarkovsky, Regina
Janga, Kalyana C.
Greenberg, Sheldon
Sharma, Shree K.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-08
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Hyponatremia is one of the most commonly encountered electrolyte abnormalities occurring in up to 22% of hospitalized patients.
Hyponatremia usually reflects excess water retention relative to sodium rather than sodium deficiency.
Volume status and serum osmolality are essential to determine etiology.
Treatment depends on several factors, including the cause, overall volume status of the patient, severity of hyponatremic symptoms, and duration of hyponatremia at presentation.
Vasopressin antagonists like tolvaptan seem promising for the treatment of euvolemic and hypervolemic hyponatremia in heart failure.
Low sodium concentrations cause cerebral edema, but the overly rapid sodium correction can also lead to iatrogenic cerebral osmotic demyelination syndrome.
Demyelination may occur days after sodium correction or initial neurologic recovery from hyponatremia.
The following case report analyzes the role of vasopressin antagonists in the treatment of hyponatremia and the need for daily dosing of tolvaptan and the monitoring of serum sodium levels to avoid rapid overcorrection which can result in osmotic demyelination syndrome (ODS).
American Psychological Association (APA)
Malhotra, Ishan& Gopinath, Shilpa& Janga, Kalyana C.& Greenberg, Sheldon& Sharma, Shree K.& Tarkovsky, Regina. 2014. Unpredictable Nature of Tolvaptan in Treatment of Hypervolemic Hyponatremia : Case Review on Role of Vaptans. Case Reports in Endocrinology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-499620
Modern Language Association (MLA)
Malhotra, Ishan…[et al.]. Unpredictable Nature of Tolvaptan in Treatment of Hypervolemic Hyponatremia : Case Review on Role of Vaptans. Case Reports in Endocrinology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-499620
American Medical Association (AMA)
Malhotra, Ishan& Gopinath, Shilpa& Janga, Kalyana C.& Greenberg, Sheldon& Sharma, Shree K.& Tarkovsky, Regina. Unpredictable Nature of Tolvaptan in Treatment of Hypervolemic Hyponatremia : Case Review on Role of Vaptans. Case Reports in Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-499620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499620