Physiologic Basis and Pathophysiologic Implications of the Diastolic Properties of the Cardiac Muscle
Joint Authors
Ferreira-Martins, João
Leite-Moreira, Adelino F.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Although systole was for long considered the core of cardiac function, hemodynamic performance is evenly dependent on appropriate systolic and diastolic functions.
The recognition that isolated diastolic dysfunction is the major culprit for approximately fifty percent of all heart failure cases imposes a deeper understanding of its underlying mechanisms so that better diagnostic and therapeutic strategies can be designed.
Risk factors leading to diastolic dysfunction affect myocardial relaxation and/or its material properties by disrupting the homeostasis of cardiomyocytes as well as their relation with surrounding matrix and vascular structures.
As a consequence, slower ventricular relaxation and higher myocardial stiffness may result in higher ventricular filling pressures and in the risk of hemodynamic decompensation.
Thus, determining the mechanisms of diastolic function and their implications in the pathophysiology of heart failure with normal ejection fraction has become a prominent field in basic and clinical research.
American Psychological Association (APA)
Ferreira-Martins, João& Leite-Moreira, Adelino F.. 2010. Physiologic Basis and Pathophysiologic Implications of the Diastolic Properties of the Cardiac Muscle. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-499622
Modern Language Association (MLA)
Ferreira-Martins, João& Leite-Moreira, Adelino F.. Physiologic Basis and Pathophysiologic Implications of the Diastolic Properties of the Cardiac Muscle. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-499622
American Medical Association (AMA)
Ferreira-Martins, João& Leite-Moreira, Adelino F.. Physiologic Basis and Pathophysiologic Implications of the Diastolic Properties of the Cardiac Muscle. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-499622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499622