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Incidental Prenatal Diagnosis of Sex Chromosome Aneuploidies : Health, Behavior, and Fertility
Joint Authors
Kooper, A. J. A.
Smits, A. P. T.
Pieters, Jacqueline J. P. M.
Braat, D. D. M.
van Kessel, A. Geurts
Source
ISRN Obstetrics and Gynecology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To assess the diagnostic relevance of incidental prenatal findings of sex chromosome aneuploidies.
Methods.
We searched with medical subject headings (MeSHs) and keywords in Medline and the Cochrane Library and systematically screened publications on postnatally diagnosed sex chromosomal aneuploidies from 2006 to 2011 as well as publications on incidentally prenatally diagnosed sex chromosomal aneuploidies from 1980 to 2011.
Results.
Postnatally diagnosed sex chromosomal aneuploidies demonstrated three clinical relevant domains of abnormality: physical (22–100%), behavior (0–56%), and reproductive health (47–100%), while incidentally prenatally diagnosed sex chromosomal aneuploidies demonstrated, respectively, 0–33%, 0–40%, and 0–36%.
Conclusion.
In the literature incidental prenatal diagnosis of sex chromosomal aneuploidies is associated with normal to mildly affected phenotypes.
This contrasts sharply with those of postnatally diagnosed sex chromosomal aneuploidies and highlights the importance of this ascertainment bias towards the prognostic value of diagnosis of fetal sex chromosomal aneuploidies.
This observation should be taken into account, especially when considering excluding the sex chromosomes in invasive prenatal testing using Rapid Aneuploidy Detection.
American Psychological Association (APA)
Pieters, Jacqueline J. P. M.& Kooper, A. J. A.& van Kessel, A. Geurts& Braat, D. D. M.& Smits, A. P. T.. 2011. Incidental Prenatal Diagnosis of Sex Chromosome Aneuploidies : Health, Behavior, and Fertility. ISRN Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-499624
Modern Language Association (MLA)
Pieters, Jacqueline J. P. M.…[et al.]. Incidental Prenatal Diagnosis of Sex Chromosome Aneuploidies : Health, Behavior, and Fertility. ISRN Obstetrics and Gynecology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-499624
American Medical Association (AMA)
Pieters, Jacqueline J. P. M.& Kooper, A. J. A.& van Kessel, A. Geurts& Braat, D. D. M.& Smits, A. P. T.. Incidental Prenatal Diagnosis of Sex Chromosome Aneuploidies : Health, Behavior, and Fertility. ISRN Obstetrics and Gynecology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-499624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499624