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Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4NF-κB Pathway after Traumatic Brain Injury in the Rat
Joint Authors
Pan, Hao
Wang, Handong
Zhao, Jinbing
Su, Xingfen
Mao, Lei
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ethyl pyruvate (EP) has demonstrated neuroprotective effects against acute brain injury through its anti-inflammatory action.
The nuclear protein high-mobility group box 1 (HMGB1) can activate inflammatory pathways when released from dying cells.
This study was designed to investigate the protective effects of EP against secondary brain injury in rats after Traumatic Brain Injury (TBI).
Adult male rats were randomly divided into three groups: (1) Sham + vehicle group, (2) TBI + vehicle group, and (3) TBI + EP group (n=30 per group).
Right parietal cortical contusion was made by using a weight-dropping TBI method.
In TBI + EP group, EP was administered intraperitoneally at a dosage of 75 mg/kg at 5 min, 1 and 6 h after TBI.
Brain samples were harvested at 24 h after TBI.
We found that EP treatment markedly inhibited the expressions of HMGB1 and TLR4, NF-κB DNA binding activity and inflammatory mediators, such as IL-1β, TNF-α and IL-6.
Also, EP treatment significantly ameliorated beam walking performance, brain edema, and cortical apoptotic cell death.
These results suggest that the protective effects of EP may be mediated by the reduction of HMGB1/TLR4/NF-κB-mediated inflammatory response in the injured rat brain.Erratum to “Beneficial Effects of Ethyl Pyruvate through Inhibiting High Mobility Group Box 1 Expression and TLR4/NF-κB Pathway after Traumatic Brain Injury in the Rat”dx.doi.org/10.1155/2012/794531
American Psychological Association (APA)
Su, Xingfen& Wang, Handong& Zhao, Jinbing& Pan, Hao& Mao, Lei. 2011. Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4NF-κB Pathway after Traumatic Brain Injury in the Rat. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-499627
Modern Language Association (MLA)
Su, Xingfen…[et al.]. Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4NF-κB Pathway after Traumatic Brain Injury in the Rat. Mediators of Inflammation No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-499627
American Medical Association (AMA)
Su, Xingfen& Wang, Handong& Zhao, Jinbing& Pan, Hao& Mao, Lei. Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4NF-κB Pathway after Traumatic Brain Injury in the Rat. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-499627
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499627