MicroRNAs and Multiple Sclerosis
Joint Authors
Genc, Sermin
Oner, Meryem Gulfem
Tufekci, Kemal Ugur
Genc, Kursad
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-11
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
MicroRNAs (miRNAs) have recently emerged as a new class of modulators of gene expression.
miRNAs control protein synthesis by targeting mRNAs for translational repression or degradation at the posttranscriptional level.
These noncoding RNAs are endogenous, single-stranded molecules approximately 22 nucleotides in length and have roles in multiple facets of immunity, from regulation of development of key cellular players to activation and function in immune responses.
Recent studies have shown that dysregulation of miRNAs involved in immune responses leads to autoimmunity.
Multiple sclerosis (MS) serves as an example of a chronic and organ-specific autoimmune disease in which miRNAs modulate immune responses in the peripheral immune compartment and the neuroinflammatory process in the brain.
For MS, miRNAs have the potential to serve as modifying drugs.
In this review, we summarize current knowledge of miRNA biogenesis and mode of action and the diverse roles of miRNAs in modulating the immune and inflammatory responses.
We also review the role of miRNAs in autoimmunity, focusing on emerging data regarding miRNA expression patterns in MS.
Finally, we discuss the potential of miRNAs as a disease marker and a novel therapeutic target in MS.
Better understanding of the role of miRNAs in MS will improve our knowledge of the pathogenesis of this disease.
American Psychological Association (APA)
Tufekci, Kemal Ugur& Oner, Meryem Gulfem& Genc, Sermin& Genc, Kursad. 2010. MicroRNAs and Multiple Sclerosis. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-27.
https://search.emarefa.net/detail/BIM-499654
Modern Language Association (MLA)
Tufekci, Kemal Ugur…[et al.]. MicroRNAs and Multiple Sclerosis. Autoimmune Diseases No. 2011 (2011), pp.1-27.
https://search.emarefa.net/detail/BIM-499654
American Medical Association (AMA)
Tufekci, Kemal Ugur& Oner, Meryem Gulfem& Genc, Sermin& Genc, Kursad. MicroRNAs and Multiple Sclerosis. Autoimmune Diseases. 2010. Vol. 2011, no. 2011, pp.1-27.
https://search.emarefa.net/detail/BIM-499654
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499654