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ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress
Joint Authors
Xiao, Jian
Huang, Yan
Li, Xiao-kun
Zhu, Hong
Xu, Zhu-mei
Lu, Xiang-hong
Yang, Ying
Ding, Ting
Liu, Yan-Long
Lin, Yuan
Zhang, Yi
Wan, Xiao-shan
Xiao, Ye-cheng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Fibroblast growth factor 21 (FGF21) is an important endogenous regulator involved in the regulation of glucose and lipid metabolism.
FGF21 expression is strongly induced in animal and human subjects with metabolic diseases, but little is known about the molecular mechanism.
Endoplasmic reticulum (ER) stress plays an essential role in metabolic homeostasis and is observed in numerous pathological processes, including type 2 diabetes, overweight, nonalcoholic fatty liver disease (NAFLD).
In this study, we investigate the correlation between the expression of FGF21 and ER stress.
We demonstrated that TG-induced ER stress directly regulated the expression and secretion of FGF21 in a dose- and time-dependent manner.
FGF21 is the target gene for activating transcription factor 4 (ATF4) and CCAAT enhancer binding protein homologous protein (CHOP).
Suppression of CHOP impaired the transcriptional activation of FGF21 by TG-induced ER stress in CHOP−/− mouse primary hepatocytes (MPH), and overexpression of ATF4 and CHOP resulted in FGF21 promoter activation to initiate the transcriptional programme.
In mRNA stability assay, we indicated that ER stress increased the half-life of mRNA of FGF21 significantly.
In conclusion, FGF21 expression is regulated by ER stress via ATF- and CHOP-dependent transcriptional mechanism and posttranscriptional mechanism, respectively.
American Psychological Association (APA)
Wan, Xiao-shan& Lu, Xiang-hong& Xiao, Ye-cheng& Lin, Yuan& Zhu, Hong& Ding, Ting…[et al.]. 2014. ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-499692
Modern Language Association (MLA)
Wan, Xiao-shan…[et al.]. ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-499692
American Medical Association (AMA)
Wan, Xiao-shan& Lu, Xiang-hong& Xiao, Ye-cheng& Lin, Yuan& Zhu, Hong& Ding, Ting…[et al.]. ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-499692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499692