Comparison of Cell Proliferation, Protein, and Glucose Metabolism in Musculoskeletal Tumors in a PET Study
Joint Authors
Zhang, Hong
Tian, Mei
Endo, Keigo
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
11C-choline and 18F-FAMT are known to correlate with tumor cell proliferation and amino acid metabolism.
We investigated the ability of 11C-Choline and 18F-FAMT PET in diagnosis of musculoskeletal tumors in thirty-six patients in comparison of 18F-FDG PET.
11C-Choline and 18F-FDG PET were positive in all the malignant tumors (n=13), whereas 18F-FAMT was positive in 11 tumors.
The mean SUVs for malignant tumors were significantly higher than those for benign lesions in all three tracers imaging.
A moderate correlation was found between 11C-Choline and 18F-FDG (r=0.540, P<.05), or 18F-FAMT and FDG (r=0.596, P<.05).
The diagnostic sensitivity and specificity for malignancy were 91.7% and 71.4%, respectively, using 11C-choline with a SUV cut-off of 2.69.
The sensitivity and specificity of 18F-FAMT for malignancy were 66.7% and 85.7%, respectively, using a SUV cut-off of 1.26.
For 18F-FDG, using a SUV cut-off of 2.77, the sensitivity and specificity were 83.3% and 71.4%, respectively.
According to ROC analysis, the ROC curves for 11C-Choline, 18F-FAMT, and 18F-FDG were 0.855, 0.734, and 0.847, respectively.
11C-Choline PET is superior in the visualization of musculoskeletal tumors with high contrast imaging, whereas the combination of 18F-FAMT and 18F-FDG PET provides valuable information for the preoperative planning in patients with musculoskeletal tumors.
American Psychological Association (APA)
Tian, Mei& Zhang, Hong& Endo, Keigo. 2011. Comparison of Cell Proliferation, Protein, and Glucose Metabolism in Musculoskeletal Tumors in a PET Study. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-499696
Modern Language Association (MLA)
Tian, Mei…[et al.]. Comparison of Cell Proliferation, Protein, and Glucose Metabolism in Musculoskeletal Tumors in a PET Study. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-499696
American Medical Association (AMA)
Tian, Mei& Zhang, Hong& Endo, Keigo. Comparison of Cell Proliferation, Protein, and Glucose Metabolism in Musculoskeletal Tumors in a PET Study. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-499696
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499696