Hyaluronan Immobilized Polyurethane as a Blood Contacting Material
Joint Authors
Guo, Hui
Gong, Feirong
Gao, Yun
Cheng, Shujun
Lu, Yue
Source
International Journal of Polymer Science
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hyaluronan (hyaluronic acid, HA) was immobilized onto the surface of amino-functionalized polyurethane films with the goal of obtaining a novel kind of biomaterial which had the potential in blood-contacting applications.
The amino-functionalized polyurethane was prepared by synthesized acidic polyurethane whose pendant carboxyl groups were treated with an excess amount of 1,3-diaminopropane in the presence of N,N-carbonyldiimidazole (CDI).
Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), Raman spectroscopy (RS), scanning electron microscopy (SEM), and water contact angle measurement were used to confirm the surface changes at each step of treatment, both in morphologies and chemical compositions.
APTT and PT results showed that HA immobilization could prolong the blood coagulation time, thus HA-immobilized polyurethane (PU-HA) exhibited improved blood compatibility.
Cytotoxicity analysis showed that the PU-HA films synthesized in this study were cytocompatible and could support human vein endothelial cells (HUVECs) adhesion and proliferation.
American Psychological Association (APA)
Gong, Feirong& Lu, Yue& Guo, Hui& Cheng, Shujun& Gao, Yun. 2010. Hyaluronan Immobilized Polyurethane as a Blood Contacting Material. International Journal of Polymer Science،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-499698
Modern Language Association (MLA)
Gong, Feirong…[et al.]. Hyaluronan Immobilized Polyurethane as a Blood Contacting Material. International Journal of Polymer Science No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-499698
American Medical Association (AMA)
Gong, Feirong& Lu, Yue& Guo, Hui& Cheng, Shujun& Gao, Yun. Hyaluronan Immobilized Polyurethane as a Blood Contacting Material. International Journal of Polymer Science. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-499698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499698