The Yin and Yang of Innate Immunity in Stroke
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Immune system plays an elementary role in the pathophysiological progress of ischemic stroke.
It consists of innate and adaptive immune system.
Activated within minutes after ischemic onset, innate immunity is responsible for the elimination of necrotic cells and tissue repair, while it is critically involved in the initiation and amplification of poststroke inflammation that amplifies ischemic damage to the brain tissue.
Innate immune response requires days to be fully developed, providing a considerable time window for therapeutic intervention, suggesting prospect of novel immunomodulatory therapies against poststroke inflammation-induced brain injury.
However, obstacles still exist and a comprehensive understanding of ischemic stroke and innate immune reaction is essential.
In this review, we highlighted the current experimental and clinical data depicting the innate immune response following ischemic stroke, mainly focusing on the recognition of damage-associated molecular patterns, activation and recruitment of innate immune cells, and involvement of various cytokines.
In addition, clinical trials targeting innate immunity were also documented regardless of the outcome, stressing the requirements for further investigation.
American Psychological Association (APA)
Xu, Xiaomeng& Jiang, Yongjun. 2014. The Yin and Yang of Innate Immunity in Stroke. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-499701
Modern Language Association (MLA)
Xu, Xiaomeng& Jiang, Yongjun. The Yin and Yang of Innate Immunity in Stroke. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-499701
American Medical Association (AMA)
Xu, Xiaomeng& Jiang, Yongjun. The Yin and Yang of Innate Immunity in Stroke. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-499701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499701