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Detection of Myoglobin with an Open-Cavity-Based Label-Free Photonic Crystal Biosensor
Joint Authors
Ur Rahman, Shafiq
Morales, Andres
Ye, Jing Yong
Tamez-Vela, Juan Manuel
Zhang, Bailin
Tang, Liang
Bustamante, Gilbert
Solis, Steven
Peterson, Ralph
Source
Journal of Medical Engineering
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The label-free detection of one of the cardiac biomarkers, myoglobin, using a photonic-crystal-based biosensor in a total-internal-reflection configuration (PC-TIR) is presented in this paper.
The PC-TIR sensor possesses a unique open optical microcavity that allows for several key advantages in biomolecular assays.
In contrast to a conventional closed microcavity, the open configuration allows easy functionalization of the sensing surface for rapid biomolecular binding assays.
Moreover, the properties of PC structures make it easy to be designed and engineered for operating at any optical wavelength.
Through fine design of the photonic crystal structure, biochemical modification of the sensor surface, and integration with a microfluidic system, we have demonstrated that the detection sensitivity of the sensor for myoglobin has reached the clinically significant concentration range, enabling potential usage of this biosensor for diagnosis of acute myocardial infarction.
The real-time response of the sensor to the myoglobin binding may potentially provide point-of-care monitoring of patients and treatment effects.
American Psychological Association (APA)
Zhang, Bailin& Tamez-Vela, Juan Manuel& Solis, Steven& Bustamante, Gilbert& Peterson, Ralph& Ur Rahman, Shafiq…[et al.]. 2013. Detection of Myoglobin with an Open-Cavity-Based Label-Free Photonic Crystal Biosensor. Journal of Medical Engineering،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-499705
Modern Language Association (MLA)
Zhang, Bailin…[et al.]. Detection of Myoglobin with an Open-Cavity-Based Label-Free Photonic Crystal Biosensor. Journal of Medical Engineering No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-499705
American Medical Association (AMA)
Zhang, Bailin& Tamez-Vela, Juan Manuel& Solis, Steven& Bustamante, Gilbert& Peterson, Ralph& Ur Rahman, Shafiq…[et al.]. Detection of Myoglobin with an Open-Cavity-Based Label-Free Photonic Crystal Biosensor. Journal of Medical Engineering. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-499705
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499705