Potential Immune Modularly Role of Glycine in Oral Gingival Inflammation
Joint Authors
Jäger, Andreas
Winter, Jochen
Deschner, James
Kraus, Dominik
Schaumann, Teresa
Wolf, Michael
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Gingival epithelial cells (GECs) represent a physical barrier against bacteria and are involved in the processes of innate immunity.
Recently, an anti-inflammatory and immune-modulatory effect of the amino acid glycine has been demonstrated.
However, there is only little information about the immune-modulatory effects of glycine in oral tissues.
This study aimed to investigate the existence and role of the glycine receptor in gingival tissue analyzing tissues/cells from extracted human molars via immunohistochemical analysis.
In vitro, GECs were challenged by inflammatory conditions with IL-1β alone or in combination with glycine and analyzed for cytokine expression of IL6/IL8 via real-time PCR.
On protein level, the effect of nuclear translocalization of NFκB protein p65 was analyzed using immunofluorescence analysis.
A distinct proof of the GlyR in oral gingival tissue and keratinocytes could be demonstrated.
Isolated challenge of the keratinocytes with IL-1β as well as with glycine resulted in an upregulation of IL6 and IL8 mRNA expression and activation of NFκB pathway.
The presence of glycine in combination with the inflammatory stimulus led to a significant decrease in inflammatory parameters.
These results indicate a possible anti-inflammatory role of glycine in gingival inflammation and encourage further research on the utility of glycine in the prevention or therapy of inflammatory periodontitis.
American Psychological Association (APA)
Schaumann, Teresa& Kraus, Dominik& Winter, Jochen& Wolf, Michael& Deschner, James& Jäger, Andreas. 2013. Potential Immune Modularly Role of Glycine in Oral Gingival Inflammation. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-499738
Modern Language Association (MLA)
Schaumann, Teresa…[et al.]. Potential Immune Modularly Role of Glycine in Oral Gingival Inflammation. Clinical and Developmental Immunology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-499738
American Medical Association (AMA)
Schaumann, Teresa& Kraus, Dominik& Winter, Jochen& Wolf, Michael& Deschner, James& Jäger, Andreas. Potential Immune Modularly Role of Glycine in Oral Gingival Inflammation. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-499738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499738