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IgD Multiple Myeloma Paraproteinemia as a Cause of Myositis
Joint Authors
Bresolin, Nereo
Crugnola, V.
Tagliaferri, E.
Colombo, I.
Moggio, M.
Prelle, A.
Sciacco, M.
Fruguglietti, M. E.
Napoli, L.
Della Volpe, A.
Source
Neurology Research International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-19
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
A 48-years old man was diagnosed an IgD-k multiple myeloma (MM) at age 38 years for which he successfully underwent chemotherapy and bone marrow transplant.
He then developed a graft-versus-host disease (GVHD) whose manifestations included, three years later, a polymyositis, diagnosed at muscle biopsy and successfully treated with steroids.
Few months after polymyositis remission, myeloma relapsed and the patient was treated with thalidomide for six years with good remission.
Soon after thalidomide suspension, MM relapsed again and the patient came to our observation for a new onset of neuromuscular symptoms.
He underwent both muscle and peripheral nerve biopsy to discriminate between myositis (paraproteinemia versus GVHD), amyloidosis, and thalidomide toxicity.
The first muscle biopsy showed an inflammatory pattern with necrotic fibres, macrophagical invasion (CD68 positive), rare interstitial cellular infiltrates (CD8 positive and CD4 negative), widespread anti-HLA positivity and negative antiMAC.
The second muscle biopsy showed the same inflammatory pattern plus an involvement of blood vessels.
Direct immunofluorescence for IgD showed diffuse positivity along the sarcolemmal in both muscle biopsies.
Sural nerve biopsy demonstrated both demyelinating and axonal aspects with no inflammatory infiltrates, but positivity for HLA and MAC.
Congo Red was negative in both skeletal muscle and peripheral nerve.
American Psychological Association (APA)
Colombo, I.& Fruguglietti, M. E.& Napoli, L.& Sciacco, M.& Tagliaferri, E.& Della Volpe, A.…[et al.]. 2010. IgD Multiple Myeloma Paraproteinemia as a Cause of Myositis. Neurology Research International،Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-499745
Modern Language Association (MLA)
Colombo, I.…[et al.]. IgD Multiple Myeloma Paraproteinemia as a Cause of Myositis. Neurology Research International No. 2010 (2010), pp.1-3.
https://search.emarefa.net/detail/BIM-499745
American Medical Association (AMA)
Colombo, I.& Fruguglietti, M. E.& Napoli, L.& Sciacco, M.& Tagliaferri, E.& Della Volpe, A.…[et al.]. IgD Multiple Myeloma Paraproteinemia as a Cause of Myositis. Neurology Research International. 2010. Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-499745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499745