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Adaptive Immunity in Ankylosing Spondylitis : Phenotype and Functional Alterations of T-Cells before and during Infliximab Therapy
Joint Authors
Szalay, Balázs
Kovács, László
Cseh, Áron
Mészáros, Gergő
Balog, Attila
Vásárhelyi, Barna
Ács, Lilla
Deák, Magdolna
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Our aim was to assess the phenotype of T-cell subsets in patients with ankylosing spondylitis (AS), a chronic inflammatory rheumatic disease.
In addition, we also tested short-term T-cell activation characteristics.
Measurements were done in 13 AS patients before and during the intravenous therapy with anti-TNF agent infliximab (IFX).
Flow cytometry was used to determine T-cell subsets in peripheral blood and their intracellular signaling during activation.
The prevalence of Th2 and Th17 cells responsible for the regulation of adaptive immunity was higher in AS than in 9 healthy controls.
Although IFX therapy improved patients' condition, immune phenotype did not normalize.
Cytoplasmic and mitochondrial calcium responses of CD4+ and CD8+ cells to a specific activation were delayed, while NO generation was increased in AS.
NO generation normalized sooner upon IFX than calcium response.
These results suggest an abnormal immune phenotype with functional disturbances of CD4+ and CD8+ cells in AS.
American Psychological Association (APA)
Szalay, Balázs& Mészáros, Gergő& Cseh, Áron& Ács, Lilla& Deák, Magdolna& Kovács, László…[et al.]. 2011. Adaptive Immunity in Ankylosing Spondylitis : Phenotype and Functional Alterations of T-Cells before and during Infliximab Therapy. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499763
Modern Language Association (MLA)
Szalay, Balázs…[et al.]. Adaptive Immunity in Ankylosing Spondylitis : Phenotype and Functional Alterations of T-Cells before and during Infliximab Therapy. Clinical and Developmental Immunology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-499763
American Medical Association (AMA)
Szalay, Balázs& Mészáros, Gergő& Cseh, Áron& Ács, Lilla& Deák, Magdolna& Kovács, László…[et al.]. Adaptive Immunity in Ankylosing Spondylitis : Phenotype and Functional Alterations of T-Cells before and during Infliximab Therapy. Clinical and Developmental Immunology. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499763
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499763