Renoprotective Effects of AVE0991, a Nonpeptide Mas Receptor Agonist, in Experimental Acute Renal Injury
Joint Authors
Lima, Cristiano Xavier
Silveira, Kátia Daniela
Rachid, Milene
Souza dos Santos, Robson Augusto
Teixeira, Mauro Martins
Barroso, Lívia Corrêa
Bader, Michael
Souza, Danielle Gloria
Borges, Valdinéria
Simões e Silva, Ana Cristina
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Renal ischemia and reperfusion (I/R) is the major cause of acute kidney injury in hospitalized patients.
Mechanisms underlying reperfusion-associated injury include recruitment and activation of leukocytes and release of inflammatory mediators.
In this study, we investigated the renal effects of acute administration of AVE0991, an agonist of Mas, the angiotensin-(1–7) receptor, the angiotensin-(1–7) receptor, in a murine model of renal I/R.
Male C57BL/6 wild-type or Mas−/− mice were subjected to 30 min of bilateral ischemia and 24 h of reperfusion.
Administration of AVE0991 promoted renoprotective effects, as seen by improvement of function, decreased tissue injury, prevention of local and remote leucocyte infiltration, and release of the chemokine, CXCL1.
I/R injury was similar in WT and Mas−/− mice, suggesting that endogenous activation of this receptor does not control renal damage under baseline conditions.
In conclusion, pharmacological interventions using Mas receptor agonists may represent a therapeutic opportunity for the treatment of renal I/R injury.
American Psychological Association (APA)
Barroso, Lívia Corrêa& Silveira, Kátia Daniela& Lima, Cristiano Xavier& Borges, Valdinéria& Bader, Michael& Rachid, Milene…[et al.]. 2012. Renoprotective Effects of AVE0991, a Nonpeptide Mas Receptor Agonist, in Experimental Acute Renal Injury. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499764
Modern Language Association (MLA)
Barroso, Lívia Corrêa…[et al.]. Renoprotective Effects of AVE0991, a Nonpeptide Mas Receptor Agonist, in Experimental Acute Renal Injury. International Journal of Hypertension No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-499764
American Medical Association (AMA)
Barroso, Lívia Corrêa& Silveira, Kátia Daniela& Lima, Cristiano Xavier& Borges, Valdinéria& Bader, Michael& Rachid, Milene…[et al.]. Renoprotective Effects of AVE0991, a Nonpeptide Mas Receptor Agonist, in Experimental Acute Renal Injury. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499764
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499764