On the Use of Molecular Weight Cutoff Cassettes to Measure Dynamic Relaxivity of Novel Gadolinium Contrast Agents : Example Using Hyaluronic Acid Polymer Complexes in Phosphate-Buffered Saline
Joint Authors
Oviatt, Henry Wayne
Kasraie, Nima
Clarke, Geoffrey David
Source
Radiology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aims of this study were to determine whether standard extracellular contrast agents of Gd(III) ions in combination with a polymeric entity susceptible to hydrolytic degradation over a finite period of time, such as Hyaluronic Acid (HA), have sufficient vascular residence time to obtain comparable vascular imaging to current conventional compounds and to obtain sufficient data to show proof of concept that HA with Gd-DTPA ligands could be useful as vascular imaging agents.
We assessed the dynamic relaxivity of the HA bound DTPA compounds using a custom-made phantom, as well as relaxation rates at 10.72 MHz with concentrations ranging between 0.09 and 7.96 mM in phosphate-buffered saline.
Linear dependences of static longitudinal relaxation rate (R1) on concentration were found for most measured samples, and the HA samples continued to produce high signal strength after 24 hours after injection into a dialysis cassette at 3T, showing superior dynamic relaxivity values compared to conventional contrast media such as Gd-DTPA-BMA.
American Psychological Association (APA)
Kasraie, Nima& Oviatt, Henry Wayne& Clarke, Geoffrey David. 2011. On the Use of Molecular Weight Cutoff Cassettes to Measure Dynamic Relaxivity of Novel Gadolinium Contrast Agents : Example Using Hyaluronic Acid Polymer Complexes in Phosphate-Buffered Saline. Radiology Research and Practice،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-499772
Modern Language Association (MLA)
Kasraie, Nima…[et al.]. On the Use of Molecular Weight Cutoff Cassettes to Measure Dynamic Relaxivity of Novel Gadolinium Contrast Agents : Example Using Hyaluronic Acid Polymer Complexes in Phosphate-Buffered Saline. Radiology Research and Practice No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-499772
American Medical Association (AMA)
Kasraie, Nima& Oviatt, Henry Wayne& Clarke, Geoffrey David. On the Use of Molecular Weight Cutoff Cassettes to Measure Dynamic Relaxivity of Novel Gadolinium Contrast Agents : Example Using Hyaluronic Acid Polymer Complexes in Phosphate-Buffered Saline. Radiology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-499772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499772