Intake of Blueberry Fermented by Lactobacillus plantarum Affects the Gut Microbiota of L-NAME Treated Rats
Joint Authors
Ahrné, Siv
Olsson, Crister
Molin, Göran
Xu, Jie
Prykhodko, Olena
Ahrén, Irini Lazou
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Prebiotics, probiotics, or synbiotics can be used as means to regulate the microbiota to exert preventative or beneficial effects to the host.
However, not much is known about the effect of the gut microbiota on hypertension which is a major risk factor of cardiovascular disease and also a symptom of the metabolic syndrome.
The NG-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats were used in order to test the effect of a synbiotic dietary supplement of Lactobacillus plantarum HEAL19 either together with fermented blueberry or with three phenolic compounds synthesized during fermentation.
The experimental diets did not lower the blood pressure after 4 weeks.
However, the fermented blueberries together with live L.
plantarum showed protective effect on liver cells indicated by suppressed increase of serum alanine aminotransferase (ALAT) levels.
The diversity of the caecal microbiota was neither affected by L-NAME nor the experimental diets.
However, inhibition of the nitric oxide synthesis by L-NAME exerted a selection pressure that led to a shift in the bacterial composition.
The mixture of fermented blueberries with the bacterial strain altered the caecal microbiota in different direction compared to L-NAME, while the three phenolic compounds together with the bacteria eliminated the selection pressure from the L-NAME.
American Psychological Association (APA)
Xu, Jie& Ahrén, Irini Lazou& Prykhodko, Olena& Olsson, Crister& Ahrné, Siv& Molin, Göran. 2013. Intake of Blueberry Fermented by Lactobacillus plantarum Affects the Gut Microbiota of L-NAME Treated Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-499789
Modern Language Association (MLA)
Xu, Jie…[et al.]. Intake of Blueberry Fermented by Lactobacillus plantarum Affects the Gut Microbiota of L-NAME Treated Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-499789
American Medical Association (AMA)
Xu, Jie& Ahrén, Irini Lazou& Prykhodko, Olena& Olsson, Crister& Ahrné, Siv& Molin, Göran. Intake of Blueberry Fermented by Lactobacillus plantarum Affects the Gut Microbiota of L-NAME Treated Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-499789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499789